PMID- 12195370
OWN - NLM
STAT- MEDLINE
DCOM- 20020917
LR  - 20220316
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 186
IP  - 4
DP  - 2002 Aug 15
TI  - Association of symptomatic acute human parvovirus B19 infection with human 
      leukocyte antigen class I and II alleles.
PG  - 447-52
AB  - To determine the effect of the major histocompatibility complex on the 
      development of symptoms during acute human parvovirus B19 infection, we compared 
      human leukocyte antigen (HLA) class I and II alleles in 36 patients with 
      symptomatic acute B19 infection with those in >900 control subjects from 
      northwestern England. The frequency of each of HLA-DRB1*01 (P=.016), DRB1*04 
      (P=.007), and DRB1*07 (P<.0001) alleles was significantly higher in parvovirus 
      B19 patients than in control subjects. In the parvovirus group, 63.9% carried the 
      rheumatoid arthritis-associated shared epitope sequence, compared with 45% of 
      control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97-4.8; 
      P=.04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 
      95% CI, 0.8-23.9; P=.047). All symptomatic parvovirus-associated HLA-DRB1 
      molecules carry a neutrally charged glutamine at position 10 and a positively 
      charged lysine at position 12 of the first hypervariable region. HLA-B49 was 
      associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and 
      DRB1*07.
FAU - Kerr, Jonathan R
AU  - Kerr JR
AD  - Department of Microbiology, Royal Brompton Hospital, National Heart and Lung 
      Institute, Imperial College of Science, Technology, and Medicine, SW3 6NP London, 
      United Kingdom. j.kerr@ic.ac.uk
FAU - Mattey, Derek L
AU  - Mattey DL
FAU - Thomson, Wendy
AU  - Thomson W
FAU - Poulton, Kay V
AU  - Poulton KV
FAU - Ollier, William E R
AU  - Ollier WE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020724
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Parvoviridae Infections/*genetics/immunology/*physiopathology
MH  - *Parvovirus B19, Human
EDAT- 2002/08/27 10:00
MHDA- 2002/09/18 10:01
CRDT- 2002/08/27 10:00
PHST- 2002/03/05 00:00 [received]
PHST- 2002/04/23 00:00 [revised]
PHST- 2002/08/27 10:00 [pubmed]
PHST- 2002/09/18 10:01 [medline]
PHST- 2002/08/27 10:00 [entrez]
AID - JID020254 [pii]
AID - 10.1086/341947 [doi]
PST - ppublish
SO  - J Infect Dis. 2002 Aug 15;186(4):447-52. doi: 10.1086/341947. Epub 2002 Jul 24.