PMID- 12196119
OWN - NLM
STAT- MEDLINE
DCOM- 20030224
LR  - 20190707
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 30
IP  - 4
DP  - 2002 Aug
TI  - X-ray crystallographic studies of IgG-Fc gamma receptor interactions.
PG  - 481-6
AB  - Human Fc gamma receptors (Fc gamma Rs) for the Fc portion of IgG are major 
      mediators of the adaptive immune response. Crystal structures of their 
      extracellular domains were recently solved and shown to obey a common fold, 
      resulting in a heart-shaped structure. Together with the multifunctional Fc 
      fragment, whose structure was deciphered in the 1970s, the complex of an Fc gamma 
      R with Fc was recently crystallized. Its crystal structure indicates that despite 
      the dimeric character of the Fc fragment, only one Fc gamma R can bind to Fc, due 
      to an introduced asymmetry within the homodimeric Fc, as well as by binding to 
      symmetrically related residues of both Fc chains. Homology modelling suggested 
      that the other Fc gamma Rs bind the Fc in a similar manner. The resolved complex 
      structure can be regarded as a paradigm for Ig binding to Fc receptors and serves 
      as a solid base for the design of compounds interfering with complex formation. 
      Such molecules would be of invaluable benefit for the therapy of immunological 
      disorders.
FAU - Sondermann, P
AU  - Sondermann P
AD  - Max-Planck-Institut fur Biochemie, Abt. Strukturforschung, Am Klopferspitz 18a, 
      D-82152 Martinsried, Germany. sonderma@biochem.mpg.de
FAU - Oosthuizen, V
AU  - Oosthuizen V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Disulfides)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Binding Sites
MH  - Crystallography, X-Ray/methods
MH  - Disulfides
MH  - Humans
MH  - Immunoglobulin G/*chemistry
MH  - Models, Molecular
MH  - Protein Structure, Secondary
MH  - Receptors, IgG/*chemistry
RF  - 32
EDAT- 2002/08/28 10:00
MHDA- 2003/02/25 04:00
CRDT- 2002/08/28 10:00
PHST- 2002/08/28 10:00 [pubmed]
PHST- 2003/02/25 04:00 [medline]
PHST- 2002/08/28 10:00 [entrez]
AID - 10.1042/bst0300481 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2002 Aug;30(4):481-6. doi: 10.1042/bst0300481.