PMID- 12196206
OWN - NLM
STAT- MEDLINE
DCOM- 20030224
LR  - 20190707
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 30
IP  - 4
DP  - 2002 Aug
TI  - Consequences of Fc gamma receptor type III reactivity in non-organ-specific 
      autoimmune diseases.
PG  - 819-24
AB  - Polymorphonuclear neutrophils (PMNs) express constitutively the Fc gamma 
      receptors (Fc gamma Rs) Fc gamma RIIIb and Fc gamma RIIa for the Fc part of IgG, 
      and soluble Fc gamma RIIIb (sFc gamma RIIIb) has been identified. Elevated levels 
      of sFc gamma RIIIb were detected in non-organ-specific autoimmune conditions, and 
      there was a considerably decreased number of PMNs undergoing apoptosis in the 
      presence of sFc gamma RIIIb. Anti-Fc gamma RIIIb autoantibodies (autoAbs) have 
      also been described in such patients. They are not cytotoxic to these cells, but 
      they extend their survival. The anti-apoptotic signal can be transduced through 
      Fc gamma RIIa and/or CD11b, the beta-chain of the complement receptor 3. However, 
      Fc gamma RIIIb appears to be also competent. Anti-Fc gamma RIIIb-conditioned 
      supernatant from cultured PMNs induces the transcription of messenger RNA for 
      granulocyte colony-stimulating factor and granulocyte/macrophage 
      colony-stimulating factor, followed by protein synthesis. The delay in apoptosis 
      may be generated by a downregulation of the death promoter Bax. Inflammation 
      might thus be modulated by sFc gamma RIIIb and anti-Fc gamma RIIIb autoAbs in 
      systemic diseases.
FAU - Youinou, P
AU  - Youinou P
AD  - Laboratory of Immunology, Brest University Medical School Hospital, BP 824, 
      F29609 Brest Cedex, France. youinou@univ-brest.fr
FAU - Renaudineau, Y
AU  - Renaudineau Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Antigens, CD)
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Antigens, CD/immunology
MH  - Apoptosis
MH  - Autoantibodies/immunology
MH  - Autoimmune Diseases/*immunology
MH  - Cell Survival/immunology
MH  - Humans
MH  - Neutrophils/*immunology/pathology
MH  - Receptors, IgG/blood/*immunology
RF  - 30
EDAT- 2002/08/28 10:00
MHDA- 2003/02/25 04:00
CRDT- 2002/08/28 10:00
PHST- 2002/08/28 10:00 [pubmed]
PHST- 2003/02/25 04:00 [medline]
PHST- 2002/08/28 10:00 [entrez]
AID - 10.1042/bst0300819 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2002 Aug;30(4):819-24. doi: 10.1042/bst0300819.