PMID- 12198621
OWN - NLM
STAT- MEDLINE
DCOM- 20021016
LR  - 20080405
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 186
IP  - 6
DP  - 2002 Sep 15
TI  - Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala 
      hantavirus infection than the tumor necrosis factor-alpha(-308) G/A polymorphism.
PG  - 843-6
AB  - The tumor necrosis factor (TNF)-alpha(-308) G/A polymorphism (TNF-2) is in 
      linkage disequilibrium with the human leukocyte antigen (HLA)-B8-DR3 haplotype. 
      Both factors have been associated with severe Puumala hantavirus-induced 
      nephropathia epidemica (NE). To examine which part of this extended haplotype 
      might show the strongest association with the outcome of NE, the HLA-B, HLA-DRB1, 
      and TNF-alpha(-308) alleles in 116 hospital-treated patients with NE were 
      analyzed. The findings pointing to clinically severe NE were strongly associated 
      with HLA-B8-DR3 haplotype. There was a trend toward severe disease in persons 
      positive for TNF-2. This was probably due to strong linkage disequilibrium with 
      HLA-B8-DR3, since there were no differences in the clinical severity of NE when 
      TNF-2-positive/B8-DR3-negative persons were compared with 
      TNF-2-negative/B8-DR3-negative persons. It is concluded that the HLA-B8-DR3 
      haplotype is an important contributor to the course of NE. The data indicate that 
      the TNF-2 allele is not an independent risk factor for severe NE but a passive 
      component in the extended haplotype.
FAU - Makela, Satu
AU  - Makela S
AD  - Medical School, University of Tampere and Tampere University Hospital, Tampere, 
      Tampere, Finland. satu.marjo.makela@uta.fi
FAU - Mustonen, Jukka
AU  - Mustonen J
FAU - Ala-Houhala, Ilpo
AU  - Ala-Houhala I
FAU - Hurme, Mikko
AU  - Hurme M
FAU - Partanen, Jukka
AU  - Partanen J
FAU - Vapalahti, Olli
AU  - Vapalahti O
FAU - Vaheri, Antti
AU  - Vaheri A
FAU - Pasternack, Amos
AU  - Pasternack A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020816
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-B8 Antigen/*genetics
MH  - HLA-DR3 Antigen/*genetics
MH  - Haplotypes
MH  - Hemorrhagic Fever with Renal Syndrome/*genetics/*immunology
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Puumala virus/*immunology
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2002/08/29 10:00
MHDA- 2002/10/17 04:00
CRDT- 2002/08/29 10:00
PHST- 2001/12/31 00:00 [received]
PHST- 2002/05/13 00:00 [revised]
PHST- 2002/08/29 10:00 [pubmed]
PHST- 2002/10/17 04:00 [medline]
PHST- 2002/08/29 10:00 [entrez]
AID - JID011531 [pii]
AID - 10.1086/342413 [doi]
PST - ppublish
SO  - J Infect Dis. 2002 Sep 15;186(6):843-6. doi: 10.1086/342413. Epub 2002 Aug 16.