PMID- 12200200 OWN - NLM STAT- MEDLINE DCOM- 20021219 LR - 20220409 IS - 0892-0362 (Print) IS - 0892-0362 (Linking) VI - 24 IP - 5 DP - 2002 Sep-Oct TI - Diabetic neuropathies in brain are induced by deficiency of BDNF. PG - 695-701 AB - Diabetes is known to be one of the risk factors for dementia; however, neuropathic changes in the brain of patients with the disease have not been completely revealed. So in the present study, we investigated the brain function of rats with diabetes induced by streptozotocin (STZ), one of the most commonly used animal models for diabetes. In the diabetic rats, immediately working memory performance was impaired in the Y-maze task and neuronal cytoskeleton proteins such as calbindin, synaptophysin, and syntaxin were reduced. Furthermore, morphological observation by Golgi staining showed a decrease in the number of basal dendrites and abnormality of spine structure. Next, we measured the content of brain-derived neurotrophic factor (BDNF) in the diabetic brain, because BDNF is one of the essential proteins for the maintenance of neuronal functions including synapse function and neuronal transmissions. In the diabetic brains, both protein and mRNA levels of BDNF were severely reduced. These results suggest that, in diabetes, synapse dysfunction is, at least in part, caused by a failure of BDNF synthesis in the brain. FAU - Nitta, A AU - Nitta A AD - Laboratory of Molecular Biology, Gifu Pharmaceutical University, 5-6-1 Mitahora-Higashi, 502-8585 Gifu, Japan. a-nitta@med.nagoya-u.ac.jp FAU - Murai, R AU - Murai R FAU - Suzuki, N AU - Suzuki N FAU - Ito, H AU - Ito H FAU - Nomoto, H AU - Nomoto H FAU - Katoh, G AU - Katoh G FAU - Furukawa, Y AU - Furukawa Y FAU - Furukawa, S AU - Furukawa S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Neurotoxicol Teratol JT - Neurotoxicology and teratology JID - 8709538 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cytoskeletal Proteins) SB - IM MH - Animals MH - Brain/*metabolism/pathology/physiopathology MH - Brain-Derived Neurotrophic Factor/*deficiency/genetics MH - Cytoskeletal Proteins/deficiency MH - Dendrites/*metabolism/pathology MH - Diabetes Mellitus, Experimental/complications MH - Diabetic Neuropathies/*metabolism/pathology/physiopathology MH - Disease Models, Animal MH - Humans MH - Male MH - Memory Disorders/etiology/metabolism/physiopathology MH - Nerve Degeneration/etiology/metabolism/pathology MH - Rats MH - Rats, Wistar RF - 28 EDAT- 2002/08/30 10:00 MHDA- 2002/12/20 04:00 CRDT- 2002/08/30 10:00 PHST- 2002/08/30 10:00 [pubmed] PHST- 2002/12/20 04:00 [medline] PHST- 2002/08/30 10:00 [entrez] AID - S0892036202002209 [pii] AID - 10.1016/s0892-0362(02)00220-9 [doi] PST - ppublish SO - Neurotoxicol Teratol. 2002 Sep-Oct;24(5):695-701. doi: 10.1016/s0892-0362(02)00220-9.