PMID- 12200976
OWN - NLM
STAT- MEDLINE
DCOM- 20021108
LR  - 20190906
IS  - 0022-3484 (Print)
IS  - 0022-3484 (Linking)
VI  - 37
IP  - 4
DP  - 2002 Aug
TI  - Microbiological, immunological and genetic factors in family members with 
      periodontitis as a manifestation of systemic disease, associated with 
      hematological disorders.
PG  - 307-15
AB  - The microflora, immunological profiles of host defence functions, and human 
      leukocyte antigen (HLA) findings are reported for a mother, son and daughter who 
      were diagnosed as having 'periodontitis as a manifestation of systemic diseases, 
      associated with hematological disorders'. Examinations were made of the bacterial 
      flora from the periodontal pocket, neutrophil chemotaxis, neutrophil 
      phagocytosis, and the genotypes (DQB1) and serotypes (DR locus) of HLA class II 
      antigens. Phenotypic analyses of the peripheral lymphocytes were also conducted. 
      The subgingival microflora from the mother was dominated by Gram-negative rods, 
      especially Porphyromonas endodontalis, Prevotella intermedia/Prevotella 
      nigrescens and Fusobacterium nucleatum. Subgingival microflora samples from the 
      son and daughter were dominated by Gram-positive cocci and Gram-positive rods. 
      Through the use of polymerase chain reaction, Campylobacter rectus and 
      Capnocytophaga gingivalis were detected in all subjects, whereas Porphyromonas 
      gingivalis, P. intermedia, and Treponema denticola were not detected in any 
      subjects. All three subjects showed a remarkable level of depressed neutrophil 
      chemotaxis to N-formyl-methionyl-leucyl-phenylalanine, although their phagocyte 
      function levels were normal, in comparison to healthy control subjects. Each 
      subject had the same genotype, HLA-DQB1*0601, while the mother had HLA-DR2 and 
      HLA-DR8, and the son and daughter had HLA-DR2 only. In summary, the members of 
      this family showed a similar predisposition to periodontitis with regard to 
      certain host defence functions. It is suggested that the depressed neutrophil 
      chemotaxis that was identified here could be a significant risk factor for 
      periodontitis in this family.
FAU - Okada, Mitsugi
AU  - Okada M
AD  - Department of Pediatric Dentistry, Hiroshima University Faculty of Dentistry, 
      Hiroshima, Japan. mitsugi@hiroshima-u.ac.jp
FAU - Awane, Saori
AU  - Awane S
FAU - Suzuki, Junji
AU  - Suzuki J
FAU - Hino, Takamune
AU  - Hino T
FAU - Takemoto, Toshinobu
AU  - Takemoto T
FAU - Kurihara, Hidemi
AU  - Kurihara H
FAU - Miura, Kazuo
AU  - Miura K
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (HLA-DR8 antigen)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Adult
MH  - Aggressive Periodontitis/*genetics/immunology/microbiology
MH  - Campylobacter/growth & development
MH  - Capnocytophaga/growth & development
MH  - Chemotaxis, Leukocyte/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fusobacterium nucleatum/growth & development
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/analysis
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR2 Antigen/analysis
MH  - Hematologic Diseases/*genetics
MH  - Humans
MH  - Leukocytes/immunology
MH  - Male
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/immunology
MH  - Periodontal Pocket/microbiology
MH  - Phagocytosis/immunology
MH  - Phenotype
MH  - Porphyromonas/growth & development
MH  - Porphyromonas gingivalis/growth & development
MH  - Prevotella/growth & development
MH  - Prevotella intermedia/growth & development
MH  - Treponema/growth & development
EDAT- 2002/08/31 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/08/31 10:00
PHST- 2002/08/31 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/08/31 10:00 [entrez]
AID - 10.1034/j.1600-0765.2002.00659.x [doi]
PST - ppublish
SO  - J Periodontal Res. 2002 Aug;37(4):307-15. doi: 10.1034/j.1600-0765.2002.00659.x.