PMID- 12201000
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20151119
IS  - 0035-1334 (Print)
IS  - 0035-1334 (Linking)
VI  - 123
IP  - 1
DP  - 2002
TI  - Clinical and histopathological correlates of the proliferative activity in 
      squamous cell laryngeal carcinoma.
PG  - 43-6
AB  - OBJECTIVES: To elucidate the clinical and histopathological significance of the 
      proliferative activity as determined by PCNA and Ki67 levels and mitotic counting 
      (MC) in laryngeal squamous cell cancer (LSCC). STUDY DESIGN: An analysis of 
      clinical, histopathological and immunhistochemical (PCNA0 and Ki67) results of 28 
      patients, who were treated for LSCC, was made. METHODS: Clinical data of the 
      patients were reviewed and corresponding archival paraffin embedded tissue 
      samples were obtained. Histopathological studies and MC were performed, and PCNA 
      and Ki67 positivity was assessed. RESULTS: There was no association between the 
      mean values of the proliferative markers, and N stage and T stage of the patients 
      as well as laryngeal site of involvement (p > 0.05). There was a correlation 
      between the proliferative indicators and tumor grade (p < 0.05). A correlation 
      was also encountered between the PCNA, Ki67 and MC values (p = 0.02). CONCLUSION: 
      The proliferative markers studied are not reliable indicators for the presumptive 
      diagnosis of occult neck metastasis. They may be used as complementary tools to 
      the conventional histopathologic grading systems to assess the tumour 
      differentiation in LSCC.
FAU - Bayazit, Y
AU  - Bayazit Y
AD  - Faculty of Medicine, Gaziantep University, Dept. of Ear Nose and Throat, 
      Kolejtepe, Gaziantep, Turkey. bayazity@yahoo.com
FAU - Bakir, K
AU  - Bakir K
FAU - Ucak, R
AU  - Ucak R
FAU - Mumbuc, S
AU  - Mumbuc S
FAU - Ozer, E
AU  - Ozer E
FAU - Kanlikama, M
AU  - Kanlikama M
LA  - eng
PT  - Journal Article
PL  - France
TA  - Rev Laryngol Otol Rhinol (Bord)
JT  - Revue de laryngologie - otologie - rhinologie
JID - 0414144
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/immunology/*pathology
MH  - Cell Division
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/*analysis
MH  - Laryngeal Neoplasms/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Staging
MH  - Prognosis
MH  - Proliferating Cell Nuclear Antigen/*analysis
MH  - Sensitivity and Specificity
EDAT- 2002/08/31 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/08/31 10:00
PHST- 2002/08/31 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/08/31 10:00 [entrez]
PST - ppublish
SO  - Rev Laryngol Otol Rhinol (Bord). 2002;123(1):43-6.