PMID- 12201640
OWN - NLM
STAT- MEDLINE
DCOM- 20030305
LR  - 20220310
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 12
IP  - 4
DP  - 2002
TI  - BDNF-triggered events in the rat hippocampus are required for both short- and 
      long-term memory formation.
PG  - 551-60
AB  - Information storage in the brain is a temporally graded process involving 
      different memory types or phases. It has been assumed for over a century that one 
      or more short-term memory (STM) processes are involved in processing new 
      information while long-term memory (LTM) is being formed. Because brain-derived 
      neutrophic factor (BDNF) modulates both short-term synaptic function and 
      activity-dependent synaptic plasticity in the adult hippocampus, we examined the 
      role of BDNF in STM and LTM formation of a hippocampal-dependent one-trial 
      fear-motivated learning task in rats. Using a competitive RT-PCR quantitation 
      method, we found that inhibitory avoidance training is associated with a rapid 
      and transient increase in BDNF mRNA expression in the hippocampus. Bilateral 
      infusions of function-blocking anti-BDNF antibody into the CA, region of the 
      dorsal hippocampus decreased extracellular signal-regulated kinase 2 (ERK2) 
      activation and impaired STM retention scores. Inhibition of ERK1/2 activation by 
      PD098059 produced similar effects. In contrast, intrahippocampal administration 
      of recombinant human BDNF increased ERK1/2 activation and facilitated STM. The 
      infusion of anti-BDNF antibody impaired LTM when given 15 min before or 1 and 4 
      hr after training, but not at 0 or 6 hr posttraining, indicating that two 
      hippocampal BDNF-sensitive time windows are critical for LTM formation. At the 
      same time points, PD098059 produced no LTM deficits. Thus, our results indicate 
      that endogenous BDNF is required for both STM and LTM formation of an inhibitory 
      avoidance learning. Additionally, they suggest that this requirement involves 
      ERK1/2-dependent and -independent mechanisms.
FAU - Alonso, Mariana
AU  - Alonso M
AD  - Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, Universidad 
      de Buenos Aires, Argentina.
FAU - Vianna, Monica R M
AU  - Vianna MR
FAU - Depino, Amaicha M
AU  - Depino AM
FAU - Mello e Souza, Tadeu
AU  - Mello e Souza T
FAU - Pereira, Patricia
AU  - Pereira P
FAU - Szapiro, German
AU  - Szapiro G
FAU - Viola, Haydee
AU  - Viola H
FAU - Pitossi, Fernando
AU  - Pitossi F
FAU - Izquierdo, Ivan
AU  - Izquierdo I
FAU - Medina, Jorge H
AU  - Medina JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Flavonoids)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - SJE1IO5E3I (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one)
SB  - IM
MH  - Animals
MH  - Antibodies/administration & dosage
MH  - Avoidance Learning/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/immunology/pharmacology/*physiology
MH  - Drug Administration Schedule
MH  - Enzyme Activation/physiology
MH  - Enzyme Inhibitors/pharmacology
MH  - Fear/physiology
MH  - Flavonoids/pharmacology
MH  - Hippocampus/*physiology
MH  - Learning/physiology
MH  - Male
MH  - Memory/drug effects/*physiology
MH  - Memory, Short-Term/*physiology
MH  - Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolism
MH  - Mitogen-Activated Protein Kinase 3
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Recombinant Proteins/pharmacology
MH  - Retention, Psychology/physiology
MH  - Time Factors
EDAT- 2002/08/31 10:00
MHDA- 2003/03/06 04:00
CRDT- 2002/08/31 10:00
PHST- 2002/08/31 10:00 [pubmed]
PHST- 2003/03/06 04:00 [medline]
PHST- 2002/08/31 10:00 [entrez]
AID - 10.1002/hipo.10035 [doi]
PST - ppublish
SO  - Hippocampus. 2002;12(4):551-60. doi: 10.1002/hipo.10035.