PMID- 12202852
OWN - NLM
STAT- MEDLINE
DCOM- 20021115
LR  - 20191106
IS  - 0883-9212 (Print)
IS  - 0883-9212 (Linking)
VI  - 22
IP  - 4
DP  - 2002 Jul-Aug
TI  - Criterion validity of the Duke Activity Status Index for assessing functional 
      capacity in patients with chronic obstructive pulmonary disease.
PG  - 298-308
AB  - PURPOSE: This study evaluated the concurrent criterion validity of the Duke 
      Activity Status Index (DASI) with respect to standard physiologic work capacity 
      indices in patients with chronic obstructive pulmonary disease (COPD) and 
      compared its performance with similar surrogates. METHODS: 119 patients with 
      moderate to severe COPD (86 men, 33 women) completed medical and smoking 
      histories, physical examination, pulmonary function testing (PFT), cycle 
      ergometry (CE), arm ergometry (AE), and 6-minute walk distance (6MWD), DASI, the 
      Sickness Impact Profile-68 (SIP-68) and the Chronic Respiratory Disease 
      Questionnaire (CRDQ). Correlation methods were used to assess the validity of the 
      potential surrogates DASI and the domain scores for SIP-68 and CRDQ, with the 
      standards CE, AE, PFT, and 6MWD (as a standard). RESULTS: The mean DASI score was 
      33.4 +/- 13.0. Significant Pearson correlations (P <.01) were observed between 
      the DASI and PFT outcomes maximum voluntary ventilation (r =.28); peak expiratory 
      flow (r =.21); diffusion capacity of lung for carbon monoxide (r =.30). For CE, 
      the correlations with DASI were oxygen consumption (VO(2))(r =.34); minute 
      ventilation (r =.25); watts (r =.37). For AE, the correlations with DASI were 
      VO(2) (r=.38); watts (r =.47). For 6MWD, the correlation was r =.53. Higher 
      correlations were obtained for the distance completed during the first minute of 
      the 6MWD and ergometric indices as well as DASI scores: watts(AE) (r =.39); 
      VO(2AE) (r =.45); watts(CE) (r =.50); VO(2CE) (r =.44). Correlation coefficients 
      for all SIP-68 and CRDQ domain and total scores were lower than corresponding 
      correlations obtained for the DASI. Regression analysis demonstrated that the 
      DASI and 6MWD were important (P <.05) for predicting VO(2) or work for CE while 
      DASI and SIP range or CRDQ dyspnea entered for AE, when gender, age, BMI, and the 
      FEV1 were forced into the model. In forward stepwise analyses, DASI entered first 
      for AE, and 6MWD entered first for CE. The DASI was selected in 3 of 4 models 
      with R(2) values ranging from.47 to.70. SIP-68 and CRDQ subscores were 
      significant as additional predictors. CONCLUSIONS: DASI has high criterion 
      validity for predicting CE and/or AE outcomes in the COPD population. It is 
      warranted in addition to the 6MWD, and its predictive significance and simplicity 
      recommends it over several other self-administered instruments for evaluating 
      functional capacity.
FAU - Carter, Rick
AU  - Carter R
AD  - Center for Clinical Research, University of Texas Health Center at Tyler, 11937 
      US Highway 271, Tyler, TX 75708, USA. Rick.Carter@UTHCT.EDU
FAU - Holiday, David B
AU  - Holiday DB
FAU - Grothues, Carol
AU  - Grothues C
FAU - Nwasuruba, Chiagozie
AU  - Nwasuruba C
FAU - Stocks, James
AU  - Stocks J
FAU - Tiep, Brian
AU  - Tiep B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiopulm Rehabil
JT  - Journal of cardiopulmonary rehabilitation
JID - 8511296
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Exercise Test
MH  - *Exercise Tolerance
MH  - Female
MH  - Health Status
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Statistics as Topic
MH  - *Surveys and Questionnaires
EDAT- 2002/08/31 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/08/31 10:00
PHST- 2002/08/31 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/08/31 10:00 [entrez]
AID - 10.1097/00008483-200207000-00014 [doi]
PST - ppublish
SO  - J Cardiopulm Rehabil. 2002 Jul-Aug;22(4):298-308. doi: 
      10.1097/00008483-200207000-00014.