PMID- 12203705
OWN - NLM
STAT- MEDLINE
DCOM- 20021120
LR  - 20131121
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 58
IP  - 2
DP  - 2002 Jul 15
TI  - Glutamatergic innervation in bone.
PG  - 70-6
AB  - Bone is highly innervated, and evidence for a regulation of bone metabolism by 
      nerve fibers has been suggested by many clinical and experimental studies. 
      However, the nature of the neuromediators involved in these processes has not 
      been well documented. Glutamate (Glu), a major neuromediator of the central 
      nervous system (CNS), was recently identified in nerve fibers running in bone 
      marrow in close contact with bone cells, suggesting that Glu may also act as a 
      neuromediator in this tissue. During the last few years, all the machinery 
      required for glutamate signalling in the CNS was demonstrated in bone. 
      Osteoblasts and osteoclasts express ionotropic Glu receptors (iGluR) (NMDA, AMPA, 
      and Kainate) and metabotropic Glu receptors (mGluR) as well as Glu transporters. 
      Electrophysiological studies have demonstrated that NMDA receptors (NMDAR) and 
      mGluR are functional on bone cells. NMDAR are involved in osteoclast formation 
      and bone resorption and preliminary studies suggest that they may also 
      participate in mechanisms underlying osteoblast proliferation or differentiation, 
      providing evidence for a direct action of Glu on bone cells. The bone loss 
      induced in a model of sciatic neurectomy in growing rats is associated with a 
      decrease of glutamatergic innervation, suggesting that Glu released by nerve 
      fibers may contribute to the regulation of bone remodeling. The manipulation of 
      Glu action in bone may, therefore, represent a new therapeutic target for 
      pathologies associated with modifications of bone remodeling.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Chenu, Chantal
AU  - Chenu C
AD  - INSERM Unit 403, Hopital E. Herriot, 69437 Lyon Cedex 03, France. 
      chenu@lyon151.inserm.fr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Receptors, Glutamate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Bone and Bones/*innervation/physiology
MH  - Central Nervous System/physiology
MH  - Glutamic Acid/metabolism/*physiology
MH  - Rats
MH  - Receptors, Glutamate/metabolism
MH  - Signal Transduction/physiology
RF  - 43
EDAT- 2002/08/31 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/08/31 10:00
PHST- 2002/08/31 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/08/31 10:00 [entrez]
AID - 10.1002/jemt.10120 [doi]
PST - ppublish
SO  - Microsc Res Tech. 2002 Jul 15;58(2):70-6. doi: 10.1002/jemt.10120.