PMID- 12208028
OWN - NLM
STAT- MEDLINE
DCOM- 20021018
LR  - 20190901
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 128
IP  - 1-2
DP  - 2002 Aug 14
TI  - Plasma, oral fluid and sweat wipe ecstasy concentrations in controlled and real 
      life conditions.
PG  - 90-7
AB  - In a double-blind placebo controlled study on psychomotor skills important for 
      car driving (Study 1), a 75 mg dose of +/- 3,4-methylenedioxymethamphetamine 
      (MDMA) was administered orally to 12 healthy volunteers who were known to be 
      recreational MDMA-users. Toxicokinetic data were gathered by analysis of blood, 
      urine, oral fluid and sweat wipes collected during the first 5h after 
      administration. Resultant plasma concentrations varied from 21 to 295 ng/ml, with 
      an average peak concentration of 178 ng/ml observed between 2 and 4h after 
      administration. MDA concentrations never exceeded 20 ng/ml. Corresponding MDMA 
      concentrations in oral fluid, as measured with a specific LC-MS/MS method (which 
      required only 50 microl of oral fluid), generally exceeded those in plasma and 
      peaked at an average concentration of 1215 ng/ml. A substantial intra- and 
      inter-subject variability was observed with this matrix, and values ranged from 
      50 to 6982 ng/ml MDMA. Somewhat surprisingly, even 4-5h after ingestion, the MDMA 
      levels in sweat only averaged 25 ng/wipe. In addition to this controlled study, 
      data were collected from 19 MDMA-users who participated in a driving simulator 
      study (Study 2), comparing sober non-drug conditions with MDMA-only and multiple 
      drug use conditions. In this particular study, urine samples were used for 
      general drug screening and oral fluid was collected as an alternative to blood 
      sampling. Analysis of oral fluid samples by LC-MS/MS revealed an average 
      MDMA/MDEA concentration of 1121 ng/ml in the MDMA-only condition, with large 
      inter-subject variability. This was also the case in the multiple drug condition, 
      where generally, significantly higher concentrations of MDMA, MDEA and/or 
      amphetamine were detected in the oral fluid samples. Urine screening revealed the 
      presence of combinations such as MDMA, MDEA, amph, cannabis, cocaine, LSD and 
      psilocine in the multiple-drug condition.
FAU - Samyn, Nele
AU  - Samyn N
AD  - Drugs and Toxicology, Section Toxicology, National Institute of Criminalistics 
      and Criminology, Vilvoordsesteenweg 100, 1120 Brussels, Belgium. 
      nele.samyn@kbcmail.net
FAU - De Boeck, Gert
AU  - De Boeck G
FAU - Wood, Michelle
AU  - Wood M
FAU - Lamers, Caroline T J
AU  - Lamers CT
FAU - De Waard, Dick
AU  - De Waard D
FAU - Brookhuis, Karel A
AU  - Brookhuis KA
FAU - Verstraete, Alain G
AU  - Verstraete AG
FAU - Riedel, Wim J
AU  - Riedel WJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Automobile Driving
MH  - Body Fluids/metabolism
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Female
MH  - Hallucinogens/*adverse effects/blood/pharmacokinetics
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects/blood/pharmacokinetics
MH  - Psychomotor Performance/*drug effects
MH  - Sweat/chemistry
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 2002/09/05 10:00
MHDA- 2002/10/19 04:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2002/10/19 04:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
AID - S0379073802001573 [pii]
AID - 10.1016/s0379-0738(02)00157-3 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2002 Aug 14;128(1-2):90-7. doi: 10.1016/s0379-0738(02)00157-3.