PMID- 12208609
OWN - NLM
STAT- MEDLINE
DCOM- 20021112
LR  - 20220624
IS  - 0928-8244 (Print)
IS  - 0928-8244 (Linking)
VI  - 34
IP  - 1
DP  - 2002 Sep 6
TI  - Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor 
      necrosis factor-alpha release from macrophages.
PG  - 73-80
AB  - Tumor necrosis factor-alpha (TNF-alpha) is one of the key cytokines elicited by 
      host macrophages upon challenge with pathogenic mycobacteria. Infection of human 
      peripheral blood mononuclear cells or the murine macrophage cell line J774A-1 
      with Mycobacterium avium induced activation of the mitogen-activated protein 
      kinases (MAPKs) ERK1/2, p38 and c-Jun N-terminal kinase. U0126, an MEK-specific 
      inhibitor, abrogated M. avium-induced TNF-alpha secretion. Transfection of cells 
      with dominant-negative MEK1 led to the suppression of TNF-alpha release in M. 
      avium-challenged macrophages. M. avium activated p38 MAPK and use of the p38 MAPK 
      inhibitor, SB203580, revealed that the p38 signaling pathway negatively regulates 
      activation of ERK1/2 and release of TNF-alpha. Taken together, these results 
      provide evidence that M. avium-induced TNF-alpha release from macrophages depends 
      on an interplay between the ERK1/2 and the p38 MAPK signaling pathways.
CI  - Copyright 2002 Federation of European Microbiological Societies
FAU - Bhattacharyya, Asima
AU  - Bhattacharyya A
AD  - Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, 
      Kolkata 700 009, India.
FAU - Pathak, Shresh
AU  - Pathak S
FAU - Kundu, Manikuntala
AU  - Kundu M
FAU - Basu, Joyoti
AU  - Basu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 1)
RN  - EC 2.7.12.2 (MAP2K1 protein, human)
RN  - EC 2.7.12.2 (Map2k1 protein, mouse)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
ECI - Pathog Dis. 2022 Jun 22;80(1):. PMID: 35732596
MH  - Adult
MH  - Animals
MH  - Enzyme Activation
MH  - Enzyme Inhibitors/pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase 1
MH  - Macrophages/drug effects/*enzymology/immunology/*microbiology
MH  - Mice
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3
MH  - Mitogen-Activated Protein Kinase Kinases/genetics
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism
MH  - Models, Biological
MH  - Mycobacterium avium Complex/*pathogenicity
MH  - Protein Serine-Threonine Kinases/genetics
MH  - Transfection
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - p38 Mitogen-Activated Protein Kinases
EDAT- 2002/09/05 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
AID - S0928824402003449 [pii]
AID - 10.1111/j.1574-695X.2002.tb00605.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 2002 Sep 6;34(1):73-80. doi: 
      10.1111/j.1574-695X.2002.tb00605.x.