PMID- 12209760
OWN - NLM
STAT- MEDLINE
DCOM- 20021025
LR  - 20220330
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 95
IP  - 3
DP  - 2002 Aug 1
TI  - Clinical importance of serum interleukin-18 and nitric oxide activities in breast 
      carcinoma patients.
PG  - 663-7
AB  - BACKGROUND: Interleukin-18 (IL-18) is a novel immunoregulatory cytokine that was 
      known previously as interferon-gamma-inducing factor. IL-18 levels can be used as 
      a serum indicator for monitoring the clinical course of patients with hematologic 
      malignancies and gastric carcinoma. Nitric oxide (NO) is a pleiotropic molecule 
      that participates in the multistep processing of carcinogenesis. METHODS: In the 
      current study, we measured serum IL-18 and nitrate and nitrite levels in 38 
      metastatic and 26 nonmetastatic breast carcinoma patients and 16 healthy control 
      subjects. Serum nitrate and nitrite levels were measured as an index of NO 
      generation. RESULTS: The levels of serum IL-18 and nitrate and nitrite were 
      increased significantly in breast carcinoma patients compared with control 
      subjects (P < 0.001). Serum IL-18 levels were significantly higher in the 
      metastatic patients compared with the nonmetastatic patients (P < 0.001). There 
      was no difference in serum nitrate and nitrite levels between metastatic and 
      nonmetastatic patients (P > 0.05). Patients with bone metastasis have higher 
      serum IL-18 levels and lower serum nitrate and nitrite levels compared with 
      patients with liver, lung, and local metastasis (P < 0.001). There was no 
      correlation among serum IL-18, nitrate and nitrite, CA 15-3, and carcinoembryonic 
      antigen levels (P > 0.05). CONCLUSIONS: These findings suggest that serum IL-18 
      and nitrate and nitrite levels may be useful markers in monitoring metastatic 
      breast carcinoma patients. IL-18 and NO activities in breast carcinoma patients 
      with bone metastasis may be more valuable in the follow-up of these patients.
CI  - Copyright 2002 American Cancer Society.
FAU - Gunel, Nazan
AU  - Gunel N
AD  - Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey. 
      nazangun@hotmail.com
FAU - Coskun, Ugur
AU  - Coskun U
FAU - Sancak, Banu
AU  - Sancak B
FAU - Gunel, Ugur
AU  - Gunel U
FAU - Hasdemir, Oguz
AU  - Hasdemir O
FAU - Bozkurt, Sukru
AU  - Bozkurt S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Interleukin-18)
RN  - 0 (Mucin-1)
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/blood/*pathology
MH  - Carcinoembryonic Antigen/blood
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Middle Aged
MH  - Mucin-1/blood
MH  - Nitrates/blood
MH  - Nitric Oxide/*blood
MH  - Nitrites/blood
EDAT- 2002/09/05 10:00
MHDA- 2002/10/31 04:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
AID - 10.1002/cncr.10705 [doi]
PST - ppublish
SO  - Cancer. 2002 Aug 1;95(3):663-7. doi: 10.1002/cncr.10705.