PMID- 12210071
OWN - NLM
STAT- MEDLINE
DCOM- 20021007
LR  - 20061115
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 198
IP  - 1
DP  - 2002 Sep
TI  - Patterns of chromosomal aberrations in urinary bladder tumours and adjacent 
      urothelium.
PG  - 115-20
AB  - Bladder cancer is often characterized by recurrent and multifocal growth, and 
      tumours are frequently accompanied by precancerous alterations of the surrounding 
      urothelium. These findings have led to the hypothesis that cells from areas of 
      genetically aberrant but morphologically non-cancerous or even unremarkable 
      mucosa may be the source of bladder carcinomas. Fluorescence in situ 
      hybridization (FISH) was performed using ten probes targeting five different 
      chromosomes that are known to be frequently altered in bladder cancer (centromere 
      1, 8, 9, 11, 17 and 1p36, 8p23, 9p21, 11q13, 17p13) on paraffin-embedded tissue 
      sections of 11 superficial bladder cancers. Copy number changes of the tumours 
      were compared to those in the urothelium adjacent to the tumour. Eleven of 11 
      (100%) tumours and eight of 11 (73%) samples of adjacent urothelium showed copy 
      number changes of at least one chromosome. The occurrence of similar patterns of 
      chromosomal aberrations in the tumours and their associated urothelium supports 
      the hypothesis of a clonal relationship. It is concluded that FISH analysis 
      targeting five different chromosomes is more sensitive than conventional 
      histology for distinguishing between neoplastic and normal cells of the 
      urothelium.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Steidl, Christian
AU  - Steidl C
AD  - Gerhard-Domagk-Institute of Pathology and Department of Urology, University of 
      Muenster, Muenster, Germany.
FAU - Simon, Ronald
AU  - Simon R
FAU - Burger, Horst
AU  - Burger H
FAU - Brinkschmidt, Christian
AU  - Brinkschmidt C
FAU - Hertle, Lothar
AU  - Hertle L
FAU - Bocker, Werner
AU  - Bocker W
FAU - Terpe, Hans-Joachim
AU  - Terpe HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (DNA Probes)
SB  - IM
MH  - Carcinoma, Transitional Cell/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Precancerous Conditions/*genetics/pathology
MH  - Urinary Bladder Neoplasms/*genetics/pathology
MH  - Urothelium/pathology
EDAT- 2002/09/05 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
AID - 10.1002/path.1175 [doi]
PST - ppublish
SO  - J Pathol. 2002 Sep;198(1):115-20. doi: 10.1002/path.1175.