PMID- 12210368
OWN - NLM
STAT- MEDLINE
DCOM- 20020926
LR  - 20171116
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 26
IP  - 3
DP  - 2002 Sep
TI  - Apoptosis and apoptosis-related proteins in thyroid myopathies.
PG  - 383-8
AB  - DNA fragmentation and apoptosis-related proteins have been investigated in 
      thyroid cells and there is evidence that Fas-mediated apoptosis is inhibited by 
      thyroid stimulating hormone (TSH). We investigated DNA fragmentation by terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and Bcl-2 
      and Fas antigen expression by immunocytochemistry in skeletal muscles from 12 
      patients with hypothyroid myopathy and 5 patients with hyperthyroid myopathy. The 
      finding of very few TUNEL-positive muscle fibers in both conditions suggests that 
      apoptosis does not play a role in the pathogenesis of thyroid myopathies. Bcl-2 
      expression increased significantly in hypothyroid myopathy, correlating with high 
      serum TSH levels, and not with either triiodothyronine (T3) or thyroxine (T4) 
      serum levels. By contrast, Fas antigen was overexpressed in hyperthyroid 
      myopathy, correlating with low TSH levels. These findings suggest an 
      anti-apoptotic role for TSH itself in skeletal muscle.
CI  - Copyright 2002 Wiley Periodicals, Inc.
FAU - Monici, Maria C
AU  - Monici MC
AD  - Clinica Neurologia 2, Department of Neurosciences, Psychiatry and 
      Anaesthesiology, Policlinico Universitario, 98125 Messina, Italy.
FAU - Rodolico, Carmelo
AU  - Rodolico C
FAU - Toscano, Antonio
AU  - Toscano A
FAU - Messina, Sonia
AU  - Messina S
FAU - Benvenga, Salvatore
AU  - Benvenga S
FAU - Messina, Corrado
AU  - Messina C
FAU - Vita, Giuseppe
AU  - Vita G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (fas Receptor)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Apoptosis
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/chemistry/*pathology
MH  - Muscular Atrophy/etiology/pathology
MH  - Muscular Diseases/etiology/*pathology
MH  - Proto-Oncogene Proteins c-bcl-2/analysis
MH  - Thyroid Diseases/blood/complications/*pathology
MH  - Thyrotropin/blood
MH  - fas Receptor/analysis
EDAT- 2002/09/05 10:00
MHDA- 2002/09/27 06:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2002/09/27 06:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
AID - 10.1002/mus.10212 [doi]
PST - ppublish
SO  - Muscle Nerve. 2002 Sep;26(3):383-8. doi: 10.1002/mus.10212.