PMID- 12210418
OWN - NLM
STAT- MEDLINE
DCOM- 20021030
LR  - 20240328
IS  - 0146-6615 (Print)
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 68
IP  - 2
DP  - 2002 Oct
TI  - Human herpesvirus 6 and multiple sclerosis: a study of T cell cross-reactivity to 
      viral and myelin basic protein antigens.
PG  - 268-72
AB  - Several reports have suggested an association of human herpesvirus 6 (HHV-6) with 
      multiple sclerosis. Autoreactive T lymphocytes directed against myelin components 
      seem to contribute to the pathogenesis of the disease. It has been suggested that 
      molecular mimicry between viral and self-antigens might be one of the mechanisms 
      that determine the onset of several autoimmune diseases. Following this 
      hypothesis, the purpose of the present study was to evaluate if HHV-6 could play 
      a role in activating T cells capable of cross-reaction with an important myelin 
      component, the myelin basic protein. T cell lines were established from 22 
      multiple sclerosis patients and from 16 healthy controls, and their capability to 
      react to both virus and myelin basic protein antigens was compared. The analysis 
      of T cell cross-reactivity in patients and controls did not show significant 
      differences in the HHV-6 ability to activate myelin basic protein-reactive T 
      cells. Similarly, the evaluation of the humoral immune response to HHV-6 in 
      patients and controls did not mirror any abnormality in the HHV-6 status in 
      multiple sclerosis patients. Therefore, although the findings of activity in 
      vitro of T cell lines with dual specificity are consistent with the hypothesis of 
      molecular mimicry, the lack of differences in cross-reactivity between patients 
      and controls do not support molecular mimicry as an important mechanism in the 
      physiopathology of this disease.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Cirone, Mara
AU  - Cirone M
AD  - Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Roma, 
      Italy.
FAU - Cuomo, Laura
AU  - Cuomo L
FAU - Zompetta, Claudia
AU  - Zompetta C
FAU - Ruggieri, Stefano
AU  - Ruggieri S
FAU - Frati, Luigi
AU  - Frati L
FAU - Faggioni, Alberto
AU  - Faggioni A
FAU - Ragona, Giuseppe
AU  - Ragona G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antigens, Viral)
RN  - 0 (Myelin Basic Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigens, Viral
MH  - Autoimmunity
MH  - Case-Control Studies
MH  - Cell Line
MH  - Cross Reactions
MH  - Female
MH  - Herpesvirus 6, Human/*immunology/pathogenicity
MH  - Humans
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Models, Immunological
MH  - Molecular Mimicry
MH  - Multiple Sclerosis/*etiology/immunology/virology
MH  - Myelin Basic Protein/*immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC7167112
EDAT- 2002/09/05 10:00
MHDA- 2002/11/01 04:00
PMCR- 2020/04/19
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2002/11/01 04:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
PHST- 2020/04/19 00:00 [pmc-release]
AID - JMV10190 [pii]
AID - 10.1002/jmv.10190 [doi]
PST - ppublish
SO  - J Med Virol. 2002 Oct;68(2):268-72. doi: 10.1002/jmv.10190.