PMID- 12211274
OWN - NLM
STAT- MEDLINE
DCOM- 20030610
LR  - 20041117
IS  - 1532-0820 (Print)
IS  - 1532-0820 (Linking)
VI  - 52
IP  - 4
DP  - 2002 Aug
TI  - Evaluation of a spontaneous canine model of immunoglobulin E-mediated food 
      hypersensitivity: dynamic changes in serum and fecal allergen-specific 
      immunoglobulin E values relative to dietary change.
PG  - 316-21
AB  - The purpose of the pilot study reported here was to evaluate serum and fecal 
      total and allergen-specific immunoglobulin E (IgE) responses to dietary change in 
      five Maltese x beagle dogs with suspected food hypersensitivity, compared with 
      those of five clinically normal dogs. Clinical parameters (pruritus, otitis, and 
      diarrhea) improved in the Maltese x beagle dogs during feeding of a novel diet, 
      and signs were exacerbated by oral allergen provocation. Relative concentrations 
      of serum and fecal wheat-, corn-, and milk-specific IgE were determined by use of 
      an ELISA. The onset of clinical signs of disease was accompanied by an increase 
      in serum allergen-specific IgE concentrations. In contrast, changes in clinical 
      signs of disease or allergen-specific IgE values were not seen in the control 
      group undergoing the same regimen. Total serum IgE concentration was measured by 
      use of the ELISA, and comparison with known quantities of a monoclonal IgE 
      allowed absolute values to be reported. Values were high in the Maltese x beagle 
      colony (7 to 34 microg/ml), compared with those in the control dogs (0.7 to 6 
      microg/ml). Total serum and total fecal IgE concentrations did not change in 
      either group during the study. Although allergen-specific IgE was detected in the 
      feces of both groups, significant interassay variability made interpretation of 
      the results difficult. The authors concluded that these Maltese x beagle dogs 
      satisfied the currently recognized clinical criteria for the diagnosis of canine 
      food hypersensitivity. Furthermore, the clinical and serologic responses seen in 
      these dogs in response to oral allergen provocation suggest that this may be a 
      useful model for the study of spontaneous food hypersensitivity.
FAU - Jackson, Hilary A
AU  - Jackson HA
AD  - Comparative Allergy Program, College of Veterinary Medicine, North Carolina State 
      University, Raleigh 27606, USA.
FAU - Hammerberg, Bruce
AU  - Hammerberg B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Comp Med
JT  - Comparative medicine
JID - 100900466
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Diet
MH  - Disease Models, Animal
MH  - *Dogs
MH  - *Feces
MH  - Female
MH  - Food Hypersensitivity/*immunology/veterinary
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Milk/immunology
MH  - Otitis Externa/immunology
MH  - Pilot Projects
MH  - Skin Diseases/immunology/veterinary
MH  - Zea mays/immunology
EDAT- 2002/09/05 10:00
MHDA- 2003/06/11 05:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2003/06/11 05:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
PST - ppublish
SO  - Comp Med. 2002 Aug;52(4):316-21.