PMID- 12211352
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20190906
IS  - 0365-5237 (Print)
IS  - 0365-5237 (Linking)
IP  - 548
DP  - 2002
TI  - Human leukocyte antigen-A, -B, -C and -DR alleles and soluble human leukocyte 
      antigen class I serum level in Meniere's disease.
PG  - 26-9
AB  - Previous studies have suggested that many human leukocyte antigen (HLA)-A, -B, -C 
      and -DR alleles are associated with Meniere's disease (MD), an inner ear disorder 
      with a proposed autoimmune etiopathogenesis. Despite some discrepancies many 
      reports are in agreement with a hypothesis suggesting an influence of 
      serologically detected HLA-C products in the susceptibility to the disease. To 
      confirm these data we investigated the distribution of HLA-A, -B, -C and -DR 
      antigens that well define the HLA polymorphism using DNA typing. Furthermore, as 
      autoimmune factors have been claimed to play a role in MD, we investigated the 
      serum level of soluble HLA class I (sHLA-I). Molecular typing of HLA class I and 
      II was performed using polymerase chain reaction sequence-specific primers in 41 
      patients affected by MD, 34 patients affected by other inner ear diseases (OIDs) 
      and 101 healthy subjects. An ELISA technique was employed to investigate the 
      serum level of sHLA-I in 17 MD patients, 10 OID patients and 83 healthy subjects. 
      The results showed a significantly increased frequency of the Cw*07 specificities 
      in MD patients when compared to OID patients (63.4% vs 32.3%; p = 6.9 x 10(-3); 
      relative risk [RR] = 3.6) and healthy subjects (63.4% vs 35.6%; p = 2.28 x 
      10(-3); RR = 3.1). The sHLA-I concentrations detected in sera did not differ 
      significantly between MD patients (616 +/- 271 ng/ml), OID patients (570 +/- 307 
      ng/ml) and healthy subjects (518 +/- 340 ng/ml).
FAU - Melchiorri, Loredana
AU  - Melchiorri L
AD  - Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy.
FAU - Martini, Alessandro
AU  - Martini A
FAU - Rizzo, Roberta
AU  - Rizzo R
FAU - Berto, Anna
AU  - Berto A
FAU - Adinolfi, Elena
AU  - Adinolfi E
FAU - Baricord, Olavio Roberto
AU  - Baricord OR
LA  - eng
PT  - Journal Article
PL  - Norway
TA  - Acta Otolaryngol Suppl
JT  - Acta oto-laryngologica. Supplementum
JID - 0370355
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Gene Frequency
MH  - Genetic Linkage
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*blood/*genetics
MH  - Humans
MH  - Meniere Disease/blood/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
EDAT- 2002/09/05 10:00
MHDA- 2003/01/31 04:00
CRDT- 2002/09/05 10:00
PHST- 2002/09/05 10:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2002/09/05 10:00 [entrez]
AID - 10.1080/00016480260094938 [doi]
PST - ppublish
SO  - Acta Otolaryngol Suppl. 2002;(548):26-9. doi: 10.1080/00016480260094938.