PMID- 12214582
OWN - NLM
STAT- MEDLINE
DCOM- 20020925
LR  - 20061115
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 70
IP  - 4
DP  - 2002 Aug
TI  - Trisomies 8 and 9 not detected with fish in patients with mastocytosis.
PG  - 324-5
AB  - Mastocytosis is a rare disease characterized by proliferation of mast cells in 
      one or several organs. With conventional cytogenetics about 35% of the patients 
      have chromosomally abnormal clones in bone marrow cells. It has been proposed to 
      include the mast cell disease among the myeloproliferative disorders, in which 
      trisomy for chromosome 8 and 9 can appear in the bone marrow cells. In this study 
      bone marrow cells from eight patients with mastocytosis, two had as well an 
      associated hematological disease, have been examined with fluorescence in situ 
      hybridization (FISH) for enumeration of chromosome no8 and 9. In conventional 
      cytogenetics two patients had clones with del(20) and 47,XY,+14/45, X,-Y, 
      respectively. None of the patients with mastocytosis had clones with trisomy 8 or 
      9 with either cytogenetics or FISH.
FAU - Swolin, Birgitta
AU  - Swolin B
AD  - Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University 
      Hospital, Goteborg University, Sweden. Birgitta.Swolin@clinchem.gu.se
FAU - Rodjer, Stig
AU  - Rodjer S
FAU - Ogard, Inger
AU  - Ogard I
FAU - Roupe, Gosta
AU  - Roupe G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow Cells
MH  - *Chromosomes, Human, Pair 8
MH  - *Chromosomes, Human, Pair 9
MH  - Cytogenetics/standards
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/standards
MH  - Mastocytosis/*genetics
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - *Trisomy/diagnosis/genetics
EDAT- 2002/09/07 10:00
MHDA- 2002/09/26 06:00
CRDT- 2002/09/07 10:00
PHST- 2002/09/07 10:00 [pubmed]
PHST- 2002/09/26 06:00 [medline]
PHST- 2002/09/07 10:00 [entrez]
AID - 10.1002/ajh.10147 [doi]
PST - ppublish
SO  - Am J Hematol. 2002 Aug;70(4):324-5. doi: 10.1002/ajh.10147.