PMID- 12218695
OWN - NLM
STAT- MEDLINE
DCOM- 20021023
LR  - 20231120
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 13
IP  - 12
DP  - 2002 Aug 27
TI  - Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate 
      gyrus.
PG  - 1509-13
AB  - It is generally accepted that alcohol and nicotine affect learning ability and 
      memory functions, especially in adolescents. In the present study, the effects of 
      alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of 
      young rats were investigated. The results show that cell proliferation is 
      suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase 
      the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL)-positive cells. Based on the results presented in this study, it 
      can be suggested that alcohol- and nicotine-related impairment in learning and 
      memory functions may be due to alcohol- and nicotine-induced suppression of new 
      cell formation and acceleration of apoptosis, especially during adolescence.
CI  - Copyright 2002 Lippincott Williams & Wilkins.
FAU - Jang, Mi-Hyeon
AU  - Jang MH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, 1 
      Hoigi-dong, Dongdaemoon-gu, Seoul 130-701.
FAU - Shin, Min-Chul
AU  - Shin MC
FAU - Jung, Sae-Bin
AU  - Jung SB
FAU - Lee, Taeck-Hyun
AU  - Lee TH
FAU - Bahn, Geon-Ho
AU  - Bahn GH
FAU - Kwon, Yunhee Kim
AU  - Kwon YK
FAU - Kim, Ee-Hwa
AU  - Kim EH
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Antimetabolites)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Nicotinic Agonists)
RN  - 3K9958V90M (Ethanol)
RN  - 6M3C89ZY6R (Nicotine)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Antimetabolites
MH  - Apoptosis/*drug effects
MH  - Bromodeoxyuridine
MH  - Cell Division/drug effects
MH  - Central Nervous System Depressants/*pharmacology
MH  - Dentate Gyrus/*cytology/drug effects
MH  - Ethanol/*pharmacology
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Nicotine/*pharmacology
MH  - Nicotinic Agonists/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2002/09/10 10:00
MHDA- 2002/10/31 04:00
CRDT- 2002/09/10 10:00
PHST- 2002/09/10 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/09/10 10:00 [entrez]
AID - 10.1097/00001756-200208270-00004 [doi]
PST - ppublish
SO  - Neuroreport. 2002 Aug 27;13(12):1509-13. doi: 10.1097/00001756-200208270-00004.