PMID- 12220579
OWN - NLM
STAT- MEDLINE
DCOM- 20021220
LR  - 20220330
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 114
IP  - 3
DP  - 2002
TI  - BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus.
PG  - 795-805
AB  - There is increasing evidence that brain-derived neurotrophic factor (BDNF) 
      modulates synaptic and morphological plasticity in the developing and mature 
      nervous system. Plasticity may be modulated partially by BDNF's effects on 
      dendritic structure. Utilizing transgenic mice where BDNF overexpression was 
      controlled by the beta-actin promoter, we evaluated the effects of long-term 
      overexpression of BDNF on the dendritic structure of granule cells in the 
      hippocampal dentate gyrus. BDNF transgenic mice provided the opportunity to 
      investigate the effects of modestly increased BDNF levels on dendrite structure 
      in the complex in vivo environment. While the elevated BDNF levels were 
      insufficient to change levels of TrkB receptor isoforms or downstream TrkB 
      signaling, they did increase dendrite complexity of dentate granule cells. These 
      cells showed an increased number of first order dendrites, of total dendritic 
      length and of total number of branch points. These results suggest that dendrite 
      structure of granule cells is tightly regulated and is sensitive to modest 
      increases in levels of BDNF. This is the first study to evaluate the effects of 
      BDNF overexpression on dendrite morphology in the intact hippocampus and extends 
      previous in vitro observations that BDNF influences synaptic plasticity by 
      increasing complexity of dendritic arbors.
CI  - Copyright 2002 IBRO
FAU - Tolwani, R J
AU  - Tolwani RJ
AD  - Department of Comparative Medicine, Stanford University School of Medicine, 
      Stanford, CA 94305, USA.
FAU - Buckmaster, P S
AU  - Buckmaster PS
FAU - Varma, S
AU  - Varma S
FAU - Cosgaya, J M
AU  - Cosgaya JM
FAU - Wu, Y
AU  - Wu Y
FAU - Suri, C
AU  - Suri C
FAU - Shooter, E M
AU  - Shooter EM
LA  - eng
GR  - K01-RR00129/RR/NCRR NIH HHS/United States
GR  - NS04270/NS/NINDS NIH HHS/United States
GR  - NS40276/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Dendrites/*metabolism
MH  - Dentate Gyrus/cytology/metabolism
MH  - Hippocampus/cytology/*metabolism
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Mice, Transgenic
MH  - Neuronal Plasticity/physiology
EDAT- 2002/09/11 10:00
MHDA- 2002/12/21 04:00
CRDT- 2002/09/11 10:00
PHST- 2002/09/11 10:00 [pubmed]
PHST- 2002/12/21 04:00 [medline]
PHST- 2002/09/11 10:00 [entrez]
AID - S0306452202003019 [pii]
AID - 10.1016/s0306-4522(02)00301-9 [doi]
PST - ppublish
SO  - Neuroscience. 2002;114(3):795-805. doi: 10.1016/s0306-4522(02)00301-9.