PMID- 12221669
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20131121
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 71
IP  - 1
DP  - 2002 Sep
TI  - Poor response to prednisolone of idiopathic thrombocytopenia with human 
      T-lymphotropic virus type I infection.
PG  - 20-3
AB  - We describe the unique clinical characteristics of patients with idiopathic 
      thrombocytopenic purpura (ITP) who are infected by human T-lymphotropic virus 
      type I (HTLV-I). Thirty-seven patients with ITP were examined in the present 
      study: 10 patients had HTLV-I infection, and the remaining 27 did not. The mean 
      age of the group with HTLV-I infection was significantly older than that of the 
      group without infection (57.8 +/- 14.0 and 42.4 +/- 20.1, P = 0.022). The 
      difference in mean platelet counts at diagnosis between the two groups was not 
      significant, 29 x 10(9)/L and 21 x 10(9)/L, respectively. The levels of platelet 
      associated IgG, red blood cell count, white blood cell count, bone marrow cell 
      count, and megakaryocyte count did not show any significant difference. Nine 
      patients in the group with HTLV-I infection were treated with prednisolone (1 
      mg/kg, daily oral). Only 3 of them responded to the therapy (one complete 
      response [CR] and two partial responses [PR]). However, 17 of 22 patients not 
      infected with HTLV-I were treated with prednisolone successfully: 14 patients 
      achieved CR, and 3 patients achieved PR. There was a significant difference in 
      response to prednisolone between the two groups (P = 0.034). Two patients with 
      the infection and one patient without the infection achieved CR with splenectomy. 
      These results suggest that HTLV-I infection may cause immune thrombocytopenia by 
      a different mechanism than classical ITP; HTLV-I may modify the clinical features 
      of ITP through an unknown immune pathway.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Matsushita, Kakushi
AU  - Matsushita K
AD  - First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 
      Kagoshima, Japan.
FAU - Arima, Naomichi
AU  - Arima N
FAU - Ohtsubo, Hideo
AU  - Ohtsubo H
FAU - Fujiwara, Hiroshi
AU  - Fujiwara H
FAU - Arimura, Kosei
AU  - Arimura K
FAU - Kukita, Toshimasa
AU  - Kukita T
FAU - Ozaki, Atsuo
AU  - Ozaki A
FAU - Hidaka, Shiroh
AU  - Hidaka S
FAU - Matsumoto, Tadashi
AU  - Matsumoto T
FAU - Tei, Chuwa
AU  - Tei C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Immunosuppressive Agents)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Female
MH  - HTLV-I Infections/*complications
MH  - Hemorrhage/epidemiology/etiology
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Prednisolone/*therapeutic use
MH  - Purpura, Thrombocytopenic, Idiopathic/complications/*drug therapy
MH  - Treatment Failure
EDAT- 2002/09/11 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/09/11 10:00
PHST- 2002/09/11 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/09/11 10:00 [entrez]
AID - 10.1002/ajh.10173 [doi]
PST - ppublish
SO  - Am J Hematol. 2002 Sep;71(1):20-3. doi: 10.1002/ajh.10173.