PMID- 1222250
OWN - NLM
STAT- MEDLINE
DCOM- 19760706
LR  - 20081008
IS  - 0365-9615 (Print)
IS  - 0365-9615 (Linking)
VI  - 79
IP  - 6
DP  - 1975 Jun
TI  - [Change in cell membrane permeability, and composition and properties of 
      hexokinase during induced carcinogenesis].
PG  - 53-6
AB  - The isoenzyme hexokinase (HK) spectrum from normal rat large intestinal mucosa 
      consisted of 3 isoenzymes. In tumours of this localization induced by 
      1,2-dimethylhydrazine there proved to be a lack or marked decrease in the most 
      rapid anodic isoenzyme. Only one HK isoenzyme was found in the metastases. Km 
      (glucose) for tumour HK was 2--3 times lower than for normal intestinal HK; the 
      HK activity was detected in the serum from the 1st month of the carcinogenic 
      administration, and by the 5th month it was found in 80% of the tumour-bearing 
      animals. No serum HK activity was ever found in control rats.
FAU - Monakhov, N K
AU  - Monakhov NK
FAU - Pozharisskii, K M
AU  - Pozharisskii KM
FAU - Shvartsman, A L
AU  - Shvartsman AL
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Izmenenie pronitsaemosti kletochnykh membran, sostava i svoistv geksokinazy v 
      protsesse indutsirovannogo kantserogeneza.
PL  - Russia (Federation)
TA  - Biull Eksp Biol Med
JT  - Biulleten' eksperimental'noi biologii i meditsiny
JID - 0370627
RN  - 0 (Dimethylhydrazines)
RN  - 0 (Hydrazines)
RN  - 0 (Isoenzymes)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Adenocarcinoma/blood/chemically induced/enzymology/pathology
MH  - Animals
MH  - *Cell Membrane Permeability
MH  - *Dimethylhydrazines
MH  - Hexokinase/blood/*metabolism
MH  - *Hydrazines
MH  - Intestinal Neoplasms/blood/*chemically induced/enzymology/pathology
MH  - Intestine, Large/enzymology/pathology
MH  - Isoenzymes/blood/metabolism
MH  - Neoplasm Metastasis
MH  - Neoplasms, Experimental/blood/chemically induced/enzymology/pathology
MH  - Rats
EDAT- 1975/06/01 00:00
MHDA- 1975/06/01 00:01
CRDT- 1975/06/01 00:00
PHST- 1975/06/01 00:00 [pubmed]
PHST- 1975/06/01 00:01 [medline]
PHST- 1975/06/01 00:00 [entrez]
PST - ppublish
SO  - Biull Eksp Biol Med. 1975 Jun;79(6):53-6.