PMID- 12223280
OWN - NLM
STAT- MEDLINE
DCOM- 20021025
LR  - 20211203
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1572
IP  - 2-3
DP  - 2002 Sep 19
TI  - The mannose receptor family.
PG  - 364-86
AB  - The mannose receptor family comprises four glycoproteins each of which is a type 
      I transmembrane receptor with an N-terminal cysteine-rich domain, a single 
      fibronectin type II (FNII) domain and eight to ten C-type lectin-like domains 
      (CTLDs). Characteristically, these proteins are able to recycle between the 
      plasma membrane and the endosomal apparatus due to discrete motifs present within 
      their cytoplasmic domains. This review discusses the structure and function of 
      these four proteins-the mannose receptor (MR), the M-type receptor for secretory 
      phospholipases A(2) (PLA(2)R), DEC-205/gp200-MR6 and Endo180/uPARAP. Despite 
      their overall structural similarity, these four receptors have evolved to use 
      different domains to interact with discrete ligands. In addition, they differ in 
      their ability to mediate endocytic and phagocytic events and in their 
      intracellular destinations. Together, they represent a unique group of 
      multidomain, multifunctional receptors.
FAU - East, Lucy
AU  - East L
AD  - The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer 
      Research, Mary-Jean Mitchell Green Building Chester Beatty Laboratories, 237 
      Fulham Road, SW3 6JB, London, UK. l.east@icr.ac.uk
FAU - Isacke, Clare M
AU  - Isacke CM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Antigens, CD)
RN  - 0 (DEC-205 receptor)
RN  - 0 (Endo180)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Fibronectins)
RN  - 0 (Lectins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Ligands)
RN  - 0 (Mannose Receptor)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (PLA2R1 protein, human)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Mitogen)
RN  - 0 (Receptors, Phospholipase A2)
RN  - 9009-86-3 (Ricin)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Antigens, CD
MH  - Binding Sites
MH  - Cysteine/chemistry
MH  - Endocytosis
MH  - Extracellular Matrix Proteins/chemistry/physiology
MH  - Fibronectins/metabolism
MH  - Humans
MH  - Lectins/metabolism
MH  - *Lectins, C-Type
MH  - Ligands
MH  - Mannose Receptor
MH  - *Mannose-Binding Lectins
MH  - Membrane Glycoproteins/chemistry/*physiology
MH  - Minor Histocompatibility Antigens
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Phagocytosis
MH  - Protein Structure, Tertiary
MH  - Receptors, Cell Surface/chemistry/*physiology
MH  - Receptors, Mitogen/chemistry/*physiology
MH  - Receptors, Phospholipase A2
MH  - Ricin/chemistry
MH  - Sequence Alignment
EDAT- 2002/09/12 10:00
MHDA- 2002/10/31 04:00
CRDT- 2002/09/12 10:00
PHST- 2002/09/12 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/09/12 10:00 [entrez]
AID - S0304416502003197 [pii]
AID - 10.1016/s0304-4165(02)00319-7 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2002 Sep 19;1572(2-3):364-86. doi: 
      10.1016/s0304-4165(02)00319-7.