PMID- 12224978
OWN - NLM
STAT- MEDLINE
DCOM- 20021016
LR  - 20190717
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 138
IP  - 9
DP  - 2002 Sep
TI  - Frequency and severity of systemic disease in patients with subacute cutaneous 
      lupus erythematosus.
PG  - 1175-8
AB  - OBJECTIVE: To compare the frequency and severity of systemic disease in patients 
      with subacute cutaneous lupus erythematosus (SCLE) followed up in a dermatology 
      practice vs patients with systemic lupus erythematosus (SLE) followed up in a 
      rheumatology practice. DESIGN: Case-control comparison of patients matched for 
      age, sex, and ethnicity. SETTING: University-affiliated dermatology and 
      rheumatology practices. PATIENTS: Seventy-six patients with SCLE were compared 
      with 24 patients with SLE. INTERVENTION: All medical records were reviewed and 
      the patients were interviewed. MAIN OUTCOME MEASURES: Systemic and serologic 
      findings were compared between patients with SCLE and those with SLE. RESULTS: 
      Hematologic disorders were present in 6 patients (8%) with SCLE and in 13 
      patients (54%) with SLE (P<.001). Serositis was present in 1 patient (1%) with 
      SCLE and in 3 patients (12%) with SLE (P =.04). Renal involvement was present in 
      12 patients (16%) with SCLE and in 6 patients (25%) with SLE (P =.36). 
      Antinuclear antibodies were found in 52 patients (68%) with SCLE compared with 23 
      patients (96%) with SLE (P =.006). Anti-Ro antibodies were found in 37 patients 
      (49%) with SCLE compared with 10 patients (42%) with SLE (P =.64). Other 
      serologic abnormalities (anti-native DNA, anti-Sm antibody, or anti-U(1)RNP) were 
      present in 6 patients (8%) with SCLE compared with 15 patients (62%) with SLE 
      (P<.001). Photosensitivity was present in 65 patients (86%) with SCLE, compared 
      with 11 patients (46%) with SLE (P<.001). CONCLUSIONS: This analysis reveals a 
      dissimilar frequency of internal organ involvement between patients with SCLE and 
      SLE. Renal disease was similar in frequency and severity, and documented central 
      nervous system involvement was rare in both groups.
FAU - Black, Dana R
AU  - Black DR
AD  - Division of Dermatology, Department of Medicine, University of Louisville School 
      of Medicine, Louisville, KY 40202, USA. jefca@aol.com
FAU - Hornung, Carlton A
AU  - Hornung CA
FAU - Schneider, Paul D
AU  - Schneider PD
FAU - Callen, Jeffrey P
AU  - Callen JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/diagnosis/*epidemiology/therapy
MH  - Lupus Erythematosus, Systemic/diagnosis/*epidemiology/therapy
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Probability
MH  - Prognosis
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Distribution
EDAT- 2002/09/13 10:00
MHDA- 2002/10/17 04:00
CRDT- 2002/09/13 10:00
PHST- 2002/09/13 10:00 [pubmed]
PHST- 2002/10/17 04:00 [medline]
PHST- 2002/09/13 10:00 [entrez]
AID - dst10145 [pii]
AID - 10.1001/archderm.138.9.1175 [doi]
PST - ppublish
SO  - Arch Dermatol. 2002 Sep;138(9):1175-8. doi: 10.1001/archderm.138.9.1175.