PMID- 12226549
OWN - NLM
STAT- MEDLINE
DCOM- 20030207
LR  - 20190607
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 9
IP  - 4
DP  - 2002
TI  - The effect of statins on mRNA levels of genes related to inflammation, 
      coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial 
      cells.
PG  - 178-83
AB  - Large-scale clinical trials have demonstrated significant reductions in 
      cardiovascular events following statin therapy. The observed benefit of statin 
      therapy, however, may be greater in these trials than is to be expected from 
      lowering lipid levels alone. In order to clarify the mechanism by which statins 
      prevent cardiovascular events in vascular wall cells, we investigated the changes 
      in gene expression profiles after incubation with atorvastatin or pitavastatin in 
      cultured human umbilical vein endothelial cells using DNA microarrays. Statins 
      affected the expression levels of genes involved in inflammation, coagulation, 
      and vascular constriction. The mRNA levels for interleukin-8 (IL-8) and monocyte 
      chemoattractant protein-1 (MCP-1) decreased after statin treatment. Statins 
      reduced mRNA levels of plasminogen activator inhibitor-1 (PAI-1) and increased 
      the mRNA levels of thrombomodulin. Statins reduced the mRNA levels of 
      endothelin-1 and increased the mRNA levels of nitric oxide synthase-3 (eNOS). 
      These results show that, statins are clinically effective because of their 
      ability to change the gene expression profile of endothelial cells thereby 
      preventing vascular events.
FAU - Morikawa, Shigeru
AU  - Morikawa S
AD  - Department of Molecular Biology, Research Center for Advanced Science and 
      Technology, University of Tokyo, Meguro, Tokyo, Japan.
FAU - Takabe, Wakako
AU  - Takabe W
FAU - Mataki, Chikage
AU  - Mataki C
FAU - Kanke, Toru
AU  - Kanke T
FAU - Itoh, Takahiro
AU  - Itoh T
FAU - Wada, Youichiro
AU  - Wada Y
FAU - Izumi, Akashi
AU  - Izumi A
FAU - Saito, Yasushi
AU  - Saito Y
FAU - Hamakubo, Takao
AU  - Hamakubo T
FAU - Kodama, Tatsuhiko
AU  - Kodama T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Pyrroles)
RN  - 0 (Quinolines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, LDL)
RN  - A0JWA85V8F (Atorvastatin)
RN  - EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases)
RN  - M5681Q5F9P (pitavastatin)
SB  - IM
MH  - Atorvastatin
MH  - Blood Coagulation/genetics
MH  - Cells, Cultured
MH  - Endothelium, Vascular/cytology/*drug effects/metabolism
MH  - Heptanoic Acids/*pharmacology
MH  - Humans
MH  - Hydroxymethylglutaryl CoA Reductases/genetics
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Inflammation/genetics
MH  - Oligonucleotide Array Sequence Analysis
MH  - Pyrroles/*pharmacology
MH  - Quinolines/*pharmacology
MH  - RNA, Messenger/genetics/*metabolism
MH  - Receptors, LDL/genetics
MH  - Vasoconstriction/genetics
EDAT- 2002/09/13 10:00
MHDA- 2003/02/08 04:00
CRDT- 2002/09/13 10:00
PHST- 2002/09/13 10:00 [pubmed]
PHST- 2003/02/08 04:00 [medline]
PHST- 2002/09/13 10:00 [entrez]
AID - 10.5551/jat.9.178 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2002;9(4):178-83. doi: 10.5551/jat.9.178.