PMID- 12226977
OWN - NLM
STAT- MEDLINE
DCOM- 20021104
LR  - 20131121
IS  - 0042-465X (Print)
IS  - 0042-465X (Linking)
VI  - 118
IP  - 3
DP  - 2002 May-Jun
TI  - [Characteristics of pharmacodynamics of drugs after excimer laser surgery (an 
      experimental study)].
PG  - 32-5
AB  - Pharmacodynamics of dexamethasone, fluoromethanol, sodium diclofenak, and 
      tobramicin after photorefraction keratectomy (PRK) and intrastromal laser 
      keratectomy (ILK) was studied in rabbits. Eximer laser operations modulated the 
      barrier functions of the cornea. The highest concentrations of drugs in anterior 
      chamber humor during the first 20 min after instillations was observed after ILK 
      in comparison with the control (intact cornea). The highest coefficient of 
      effective drug diffusion through the cornea was observed after PRK in comparison 
      with ILK. The drug efficiency was higher after ILK than after PRK, which is seen 
      from the maximum concentrations of drugs entering the cornea immediately after 
      instillation and prolongation of the drug effect due to its decelerated diffusion 
      through the cornea.
FAU - Smirennaia, E V
AU  - Smirennaia EV
FAU - Maichuk, D Iu
AU  - Maichuk DIu
FAU - Kurenkov, V V
AU  - Kurenkov VV
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Osobennosti farmakodinamiki lekarstvennykh sredstv posle eksimerlazernykh 
      operatsii (eksperimental'noe issledovanie).
PL  - Russia (Federation)
TA  - Vestn Oftalmol
JT  - Vestnik oftalmologii
JID - 0415216
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - SV0CSG527L (Fluorometholone)
RN  - VZ8RRZ51VK (Tobramycin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Cornea/*drug effects/*metabolism
MH  - Dexamethasone/*pharmacology
MH  - Diclofenac/*pharmacology
MH  - Fluorometholone/*pharmacology
MH  - *Keratomileusis, Laser In Situ
MH  - Lasers, Excimer
MH  - *Photorefractive Keratectomy
MH  - Rabbits
MH  - Time Factors
MH  - Tobramycin/*pharmacology
EDAT- 2002/09/14 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/14 10:00
PHST- 2002/09/14 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/14 10:00 [entrez]
PST - ppublish
SO  - Vestn Oftalmol. 2002 May-Jun;118(3):32-5.