PMID- 12227494
OWN - NLM
STAT- MEDLINE
DCOM- 20021118
LR  - 20191025
IS  - 1343-4934 (Print)
IS  - 1343-4934 (Linking)
VI  - 44
IP  - 2
DP  - 2002 Jun
TI  - Behavior of HO-1-N-1, buccal mucosa carcinoma derived cells, on [Ca2+]i responses 
      to stimulants.
PG  - 103-8
AB  - Buccal mucosa carcinoma-derived cell line, HO-1-N-1, epithelial-like cells, was 
      obtained in order to investigate the characteristics of oral cancer cells and 
      examine the [Ca2+]i responses to stimulants, such as bradykinin (BK), histamine 
      (HIST), thapsigargin (TG), epidermal growth factor (EGF) and transforming growth 
      factor alpha (TGF alpha ). Intracellular Ca2+ influx was observed by all 
      stimulants that enhanced the [Ca2+]i response. However, intracellular Ca2+ 
      release was not observed in response to growth factors. The [Ca2+]i response of 
      BK (100 nM) was inhibited by 10 micro M of the BKB2 antagonist, D-Arg-[Hyp3, 
      Thi5,8, D-Phe7]-BK, and HIST (1 mM) was completely inhibited by 100 nM of the H1 
      antagonist, (+)-chlorpheniramine, in the presence and absence of extracellular 
      Ca2+ (1.5 mM).
FAU - Arai, Takafumi
AU  - Arai T
AD  - Department of Pharmacology, Nihon University School of Dentistry at Matsudo, 
      Chiba, Japan.
FAU - Matsumoto, Hiroko
AU  - Matsumoto H
FAU - Akimoto, Yoshiaki
AU  - Akimoto Y
FAU - Nishimura, Hitoshi
AU  - Nishimura H
FAU - Ono, Makiko
AU  - Ono M
FAU - Fujii, Akira
AU  - Fujii A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Oral Sci
JT  - Journal of oral science
JID - 9808942
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Transforming Growth Factor alpha)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 67526-95-8 (Thapsigargin)
RN  - 820484N8I3 (Histamine)
RN  - S8TIM42R2W (Bradykinin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Bradykinin/antagonists & inhibitors/pharmacology
MH  - Calcium/*metabolism
MH  - Calcium Signaling/*drug effects
MH  - Carcinoma/*metabolism/pathology
MH  - Epidermal Growth Factor/pharmacology
MH  - Epithelial Cells/drug effects/*metabolism
MH  - Histamine/pharmacology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Humans
MH  - Mouth Mucosa/pathology
MH  - Mouth Neoplasms/*metabolism/pathology
MH  - Receptors, Cell Surface/metabolism
MH  - Stimulation, Chemical
MH  - Thapsigargin/pharmacology
MH  - Transforming Growth Factor alpha/pharmacology
MH  - Tumor Cells, Cultured/drug effects/*metabolism
EDAT- 2002/09/14 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/14 10:00
PHST- 2002/09/14 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/14 10:00 [entrez]
AID - 10.2334/josnusd.44.103 [doi]
PST - ppublish
SO  - J Oral Sci. 2002 Jun;44(2):103-8. doi: 10.2334/josnusd.44.103.