PMID- 12230950
OWN - NLM
STAT- MEDLINE
DCOM- 20030926
LR  - 20081121
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 23
IP  - 9
DP  - 2002 Sep
TI  - Protective effect of polypeptide from Chlamys farreri on hairless mice damaged by 
      ultraviolet A.
PG  - 813-8
AB  - AIM: To study the protective effect of the polypeptide isolated from Chlamys 
      farreri (PCF) on hairless mice skin damaged by ultraviolet A. METHODS: Enzymes 
      and malondialdehyde (MDA) were determined by biochemical methods; the expressions 
      of Bcl-2 protein and NOS protein were examined by immunohistochemical technique. 
      The ultra-structure of the skin was observed through electronic microscope. 
      RESULTS: PCF could enhance the activities of glutathione peroxidase (GSH-px), 
      superoxide dismutase (SOD), and total anti-oxidative capacity (T-AOC). Also PCF 
      could reduce the amount of MDA, increase the expression of Bcl-2 protein, and 
      inhibit the expression of NOS protein. The ultra-structure of epidermis and 
      fibroblasts remained normal in 20 % PCF groups; there were vacuoles in smooth 
      endoplasm reticulum in epidermis of mice and the number of rough endoplasm 
      reticulum in fibroblasts was decreased in model group. CONCLUSION: PCF had the 
      protective effects on hairless mice skin damaged by ultraviolet A via its 
      anti-oxidative mechanisms.
FAU - Wang, Chun-Bo
AU  - Wang CB
AD  - Medical College Qingdao University, Qingdao 266021, China.
FAU - Yao, Ru-Yong
AU  - Yao RY
FAU - Liu, Zhan-Tao
AU  - Liu ZT
FAU - Zhong, Wei-Zhen
AU  - Zhong WZ
FAU - Liu, Xiao-Ping
AU  - Liu XP
FAU - Wang, Yue-Jun
AU  - Wang YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (Antioxidants)
RN  - 0 (Peptides)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Radiation-Protective Agents)
SB  - IM
MH  - Animals
MH  - Antioxidants/therapeutic use
MH  - Mice
MH  - Mice, Hairless
MH  - Mollusca/*chemistry
MH  - Peptides/*therapeutic use
MH  - Proto-Oncogene Proteins c-bcl-2/biosynthesis/genetics
MH  - Radiation Injuries, Experimental/metabolism/pathology/*prevention & control
MH  - Radiation-Protective Agents/*therapeutic use
MH  - Skin/radiation effects/ultrastructure
MH  - *Ultraviolet Rays
EDAT- 2002/09/17 10:00
MHDA- 2003/09/27 05:00
CRDT- 2002/09/17 10:00
PHST- 2002/09/17 10:00 [pubmed]
PHST- 2003/09/27 05:00 [medline]
PHST- 2002/09/17 10:00 [entrez]
PST - ppublish
SO  - Acta Pharmacol Sin. 2002 Sep;23(9):813-8.