PMID- 12231458
OWN - NLM
STAT- MEDLINE
DCOM- 20021126
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 951
IP  - 1
DP  - 2002 Sep 27
TI  - Regulation of neuropeptide Y in the rat amygdala following unilateral olfactory 
      bulbectomy.
PG  - 69-76
AB  - While the mechanisms are not fully understood, olfactory bulbectomy (OBX) is a 
      well-known rat model of depression and depression-related disorders such as 
      anxiety and aggression. Alterations in neuropeptide Y (NPY) levels in the brain 
      have been linked to depression and have been shown to be involved in the response 
      to stress. This study explored the possible regulation of NPY immunoreactivity in 
      specific regions of the amygdala 14 days after OBX in adult male Sprague-Dawley 
      rats (n=6). Unilateral OBX and immunohistochemistry permitted comparisons of NPY 
      in the ipsilateral amygdala with NPY in the contralateral (sham) amygdala. OBX 
      resulted in significant increases (P<0.05) in NPY immunoreactivity in the 
      anterior medial amygdala (threefold) and the posterior medial amygdala 
      (2.5-fold). These regions receive projections from the accessory olfactory bulb 
      (AOB). In contrast, the anterior and posterolateral cortical nuclei of the 
      amygdala receive projections from the main olfactory bulb (MOB). NPY was not 
      increased in these nuclei. These data show that not only does OBX increase NPY 
      immunoreactivity in the amygdala, but also suggest that the AOB plays a prominent 
      role in this regulation.
FAU - Rutkoski, Nancy J
AU  - Rutkoski NJ
AD  - Program in Neuroscience and Department of Nutrition, Food and Exercise Sciences, 
      237 Biomedical Research Facility, Florida State University Tallahassee, FL 
      32306-4340, USA.
FAU - Lerant, Anna A
AU  - Lerant AA
FAU - Nolte, Christopher M
AU  - Nolte CM
FAU - Westberry, Jenne
AU  - Westberry J
FAU - Levenson, Cathy W
AU  - Levenson CW
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Neuropeptide Y)
SB  - IM
MH  - Amygdala/*metabolism/physiopathology
MH  - Animals
MH  - Denervation
MH  - Depressive Disorder/*metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Functional Laterality/physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Neuropeptide Y/*metabolism
MH  - Olfactory Bulb/*injuries/physiopathology/surgery
MH  - Olfactory Pathways/*injuries/physiopathology/surgery
MH  - Presynaptic Terminals/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Neuropeptide Y/metabolism
MH  - Stress, Physiological/*metabolism/physiopathology
MH  - Up-Regulation/*physiology
EDAT- 2002/09/17 10:00
MHDA- 2002/11/28 04:00
CRDT- 2002/09/17 10:00
PHST- 2002/09/17 10:00 [pubmed]
PHST- 2002/11/28 04:00 [medline]
PHST- 2002/09/17 10:00 [entrez]
AID - S0006899302031360 [pii]
AID - 10.1016/s0006-8993(02)03136-0 [doi]
PST - ppublish
SO  - Brain Res. 2002 Sep 27;951(1):69-76. doi: 10.1016/s0006-8993(02)03136-0.