PMID- 12234707
OWN - NLM
STAT- MEDLINE
DCOM- 20021113
LR  - 20220317
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 29
IP  - 3
DP  - 2002 Sep
TI  - Lack of association of TNF-238A and -308A in Japanese patients with psoriasis 
      vulgaris, psoriatic arthritis and generalized pustular psoriasis.
PG  - 181-4
AB  - Tumor necrosis factor (TNF)-alpha is one of the proinflammatory cytokines and 
      immunomodulators, and has an important pathogenetic role in psoriasis. The 
      TNF-alpha gene (TNFA) is in the human leukocyte antigen (HLA) class III locus on 
      chromosome 6, which might be related to the pathogenesis of psoriasis. It has 
      been suggested that some polymorphisms of the TNFA gene promoter, especially G to 
      A conversions at nt-238 and -308 (TNF-238A and -308A), may be associated with 
      psoriasis in Caucasians. We investigated single nucleotide polymorphisms (SNPs) 
      of the TNFA gene promoter in Japanese psoriasis patients, including 18 with 
      psoriasis vulgaris (PsV), 11 with psoriatic arthritis (PsA), two with generalized 
      pustular psoriasis (GPP), and six with GPP with arthritis. The DNA fragment of 
      the TNFA gene from nt-400 to -69 was amplified by polymerase chain reaction (PCR) 
      and the products were sequenced. Although TNF-238A and other polymorphisms were 
      not found in PsV and psoriatic arthritis patients, one male patient with GPP and 
      PsA had TNF-308A. This suggests that TNFA gene promoter polymorphism in the 
      region examined is less associated with the pathogenesis of psoriasis in Japanese 
      patients, however there might be the possibility that TNFA gene promoter 
      polymorphism is associated with GPP. Further investigation will be required to 
      prove this.
FAU - Nishibu, Akiko
AU  - Nishibu A
AD  - Department of Dermatology, Fukushima Medical University School of Medicine, 1 
      Hikarigaoka, Fukushima-shi, Fukushima-ken 960-1295, Japan. nishibu@fmu.ac.jp
FAU - Oyama, Noritaka
AU  - Oyama N
FAU - Nakamura, Koichiro
AU  - Nakamura K
FAU - Kaneko, Fumio
AU  - Kaneko F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Arthritis, Psoriatic/*genetics
MH  - Base Sequence/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Psoriasis/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2002/09/18 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/18 10:00
PHST- 2002/09/18 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/18 10:00 [entrez]
AID - S0923181102000221 [pii]
AID - 10.1016/s0923-1811(02)00022-1 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2002 Sep;29(3):181-4. doi: 10.1016/s0923-1811(02)00022-1.