PMID- 12234713
OWN - NLM
STAT- MEDLINE
DCOM- 20021113
LR  - 20191025
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 29
IP  - 3
DP  - 2002 Sep
TI  - Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are 
      not associated with susceptibility to atopic dermatitis, but two of them in the 
      promoter region are associated with serum IgE levels in patients with atopic 
      dermatitis.
PG  - 222-8
AB  - Eotaxin is believed to play an important role in atopic dermatitis (AD) as a 
      potent chemoattractant and activator of eosinophils and Th2 lymphocytes. The 
      eotaxin gene is located at chromosome 17q21.1-q21.2, and linkage findings of AD 
      on chromosome 17 were reported. Recently we have identified single nucleotide 
      polymorphisms (SNPs) of eotaxin gene (-426C > T, -384A > G, 67G > A). To learn 
      whether eotaxin gene SNPs are associated with susceptibility to AD or phenotypes 
      of AD, we investigated the genotype frequencies at each SNP of the gene in AD 
      patients and in controls. We examined 140 Japanese AD patients and 140 healthy 
      Japanese individuals. Genotyping was performed using the polymerase chain 
      reaction-restriction fragment length polymorphism method. No significant 
      difference was observed in allele or genotype frequencies of any SNP between AD 
      patients and controls. Serum immunoglobulin E (IgE) levels were significantly 
      lower in CT and TT genotype than in CC (P = 0.038) in -426C > T SNP, and lower in 
      GG than in AA and AG with borderline significance (P = 0.053) in -384A > G SNP in 
      AD patients. Eotaxin gene SNPs in the promoter and exon regions are not 
      associated with susceptibility to AD, but two of them in the promoter region are 
      associated with phenotype of AD.
FAU - Tsunemi, Yuichiro
AU  - Tsunemi Y
AD  - Department of Dermatology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 
      113-8655, Japan. tsunemiy-der@h.u-tokyo.ac.jp
FAU - Saeki, Hidehisa
AU  - Saeki H
FAU - Nakamura, Koichiro
AU  - Nakamura K
FAU - Sekiya, Takashi
AU  - Sekiya T
FAU - Hirai, Koichi
AU  - Hirai K
FAU - Fujita, Hideki
AU  - Fujita H
FAU - Asano, Noriko
AU  - Asano N
FAU - Tanida, Yuka
AU  - Tanida Y
FAU - Kakinuma, Takashi
AU  - Kakinuma T
FAU - Wakugawa, Motoshi
AU  - Wakugawa M
FAU - Torii, Hideshi
AU  - Torii H
FAU - Tamaki, Kunihiko
AU  - Tamaki K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (CCL11 protein, human)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokines, CC)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chemokine CCL11
MH  - Chemokines, CC/*genetics
MH  - Child
MH  - Dermatitis, Atopic/*blood/*genetics
MH  - Exons/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
EDAT- 2002/09/18 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/18 10:00
PHST- 2002/09/18 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/18 10:00 [entrez]
AID - S0923181102000385 [pii]
AID - 10.1016/s0923-1811(02)00038-5 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2002 Sep;29(3):222-8. doi: 10.1016/s0923-1811(02)00038-5.