PMID- 12239629
OWN - NLM
STAT- MEDLINE
DCOM- 20030225
LR  - 20220408
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 21
IP  - 4
DP  - 2002 Oct
TI  - IVIg to prevent tumor metastases (Review).
PG  - 875-80
AB  - Intravenous gamma globulin (IVIg) is produced from a pool of precipitated IgG 
      from over 3,000 healthy donors. IVIg was originally given to subjects with Igs 
      deficiencies. Later on its beneficial effects on a diverse autoimmune clinical 
      conditions were revealed. Based on large experimental studies in mice as well as 
      limited clinical experience, we consider IVIg useful in preventing metastatic 
      spread. In mice, the employment of IVIg reduced significantly metastatic spread 
      of melanoma, carcinoma and sarcoma. The effect of IVIg was achieved following 
      i.v. or s.c. administration at high dose (2 g/kg body weight) and at 100 times 
      lower doses. The effect of IVIg on the prevention of metastases are diverse and 
      achieved via enhancement of IL-12 secretion and increased NK activity as well as 
      inhibition of matrix metalloproteinase-9 (MMP-9). The lack of serious side 
      effects with the remarkable decrease in metastatic spread make IVIg a suitable 
      adjuvant therapy in early and advanced cancer conditions.
FAU - Fishman, Pnina
AU  - Fishman P
AD  - Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Petach-Tikva 49100, Israel.
FAU - Bar-Yehuda, Sara
AU  - Bar-Yehuda S
FAU - Shoenfeld, Yehuda
AU  - Shoenfeld Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (Antineoplastic Agents)
RN  - 0 (gamma-Globulins)
RN  - 187348-17-0 (Interleukin-12)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Cell Division
MH  - Humans
MH  - Infusions, Intravenous
MH  - Interleukin-12/biosynthesis
MH  - Killer Cells, Natural
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Metastasis/*prevention & control
MH  - Neoplasms/*drug therapy/*pathology
MH  - Time Factors
MH  - gamma-Globulins/*therapeutic use
RF  - 48
EDAT- 2002/09/20 10:00
MHDA- 2003/02/26 04:00
CRDT- 2002/09/20 10:00
PHST- 2002/09/20 10:00 [pubmed]
PHST- 2003/02/26 04:00 [medline]
PHST- 2002/09/20 10:00 [entrez]
PST - ppublish
SO  - Int J Oncol. 2002 Oct;21(4):875-80.