PMID- 12242092
OWN - NLM
STAT- MEDLINE
DCOM- 20030318
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 451
IP  - 3
DP  - 2002 Sep 20
TI  - Effects of amphetamine derivatives and cathinone on noradrenaline-evoked 
      contractions of rat right ventricle.
PG  - 303-8
AB  - We have compared the effects of methylenedioxymethamphetamine (MDMA), 
      methylenedioxyethylamphetamine (MDEA), methylenedioxyamphetamine (MDA) and 
      cathinone on contractions to noradrenaline and isoprenaline in 1 Hz paced rat 
      right ventricular strips. Noradrenaline increased the force of contraction of 1 
      Hz paced ventricular strips with a pD(2) (-log EC(50)) of 5.64 +/- 0.07 (n = 49). 
      Cocaine (10 microM), MDMA (10 microM), MDA (10 microM) and cathinone (3 and 10 
      microM) significantly increased the potency of noradrenaline to 6.25 +/- 0.11, 
      6.48 +/- 0.13, 6.17 +/- 0.05, 6.15 +/- 0.07 and 6.27 +/- 0.10, respectively (n = 
      5-10 each) as compared with the effects of vehicle (5.42 +/- 0.08, n = 15). 
      However, MDEA (10 microM) failed to affect the potency of noradrenaline, although 
      MDEA (100 microM) significantly increased noradrenaline potency (5.98 +/- 0.12). 
      The potency of the agonist isoprenaline, which is not a substrate for the 
      noradrenaline transporter, was not increased by cocaine, MDMA, cathinone, MDA or 
      MDEA. Hence, MDMA, cathinone, MDA and MDEA share with cocaine an ability to 
      potentiate the actions of noradrenaline, an action which may involve competitive 
      blockade of the noradrenaline transporter rather than simply displacement of 
      noradrenaline. Since cocaine is linked to an increased incidence of myocardial 
      infarction, these results may have implications in terms of cardiac morbidity of 
      amphetamine derivatives and cathinone.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Cleary, Linda
AU  - Cleary L
AD  - Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephen's 
      Green, Dublin 2, Ireland.
FAU - Buber, Robert
AU  - Buber R
FAU - Docherty, James R
AU  - Docherty JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Alkaloids)
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 540EI4406J (cathinone)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Alkaloids/*pharmacology
MH  - Amphetamines
MH  - Animals
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Drug Interactions
MH  - Electric Stimulation
MH  - Heart Ventricles/drug effects
MH  - Male
MH  - Myocardial Contraction/*drug effects
MH  - Norepinephrine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2002/09/21 10:00
MHDA- 2003/03/19 04:00
CRDT- 2002/09/21 10:00
PHST- 2002/09/21 10:00 [pubmed]
PHST- 2003/03/19 04:00 [medline]
PHST- 2002/09/21 10:00 [entrez]
AID - S0014299902023051 [pii]
AID - 10.1016/s0014-2999(02)02305-1 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2002 Sep 20;451(3):303-8. doi: 10.1016/s0014-2999(02)02305-1.