PMID- 12269646
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20061115
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 89
IP  - 3
DP  - 2002 Sep
TI  - Early sensitization to house dust mite is a major risk factor for subsequent 
      development of bronchial asthma in Japanese infants with atopic dermatitis: 
      results of a 4-year followup study.
PG  - 265-70
AB  - BACKGROUND: Bronchial asthma (BA) often develops in children with atopic 
      dermatitis (AD). Identification of factors that could predict the development of 
      asthma in children with AD is useful for early intervention. OBJECTIVE: We 
      undertook a 4-year followup study to clarify the factors involved in the 
      development of BA in infants with AD. METHODS: We registered 169 infants with AD 
      who were free of BA at registration and examined the prevalence and 
      characteristics of the subsequent development of BA among these patients. 
      RESULTS: Among the patients followed for 4 years, approximately 45% experienced 
      asthma-like respiratory symptoms, and 35% were diagnosed as asthmatic patients by 
      pediatric allergologists. Patients who developed BA showed early appearance of 
      house dust mite (HDM)-specific immunoglobulin E (IgE) and persistently high 
      levels of food-specific IgE. Male sex, a positive family history of BA, and the 
      appearance of HDM-specific IgE were identified as significant risk factors for 
      the early development of BA, but the significance of these parameters decreased 
      thereafter. A positive family history of AD, the outcome of skin lesions, and 
      keeping furred pets were also identified as risk factors in a part of the 
      followup period. Among the parameters examined, the early appearance of 
      HDM-specific IgE was the most significant risk factor. CONCLUSION: Appearance of 
      HDM-specific IgE antibodies in early childhood, which seems to be mainly 
      influenced by genetic factors, is a major risk factor for the subsequent 
      development of BA in children with AD, but the influence decreases after longer 
      followup.
FAU - Ohshima, Yusei
AU  - Ohshima Y
AD  - Department of Pediatrics, Faculty of Medicine, Fukui Medical University, 
      Yoshida-gun, Japan. yohoshima@fmsrsa.fukui-med.ac.jp
FAU - Yamada, Akiko
AU  - Yamada A
FAU - Hiraoka, Masahiro
AU  - Hiraoka M
FAU - Katamura, Kenji
AU  - Katamura K
FAU - Ito, Setsuko
AU  - Ito S
FAU - Hirao, Takao
AU  - Hirao T
FAU - Akutagawa, Hiroshi
AU  - Akutagawa H
FAU - Kondo, Naomi
AU  - Kondo N
FAU - Morikawa, Akihiro
AU  - Morikawa A
FAU - Mayumi, Mitsufumi
AU  - Mayumi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/epidemiology/*etiology/immunology
MH  - Dermatitis, Atopic/*complications
MH  - Dust/adverse effects
MH  - Follow-Up Studies
MH  - Food Hypersensitivity/diagnosis
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Infant
MH  - Japan/epidemiology
MH  - Male
MH  - Mites/*immunology
MH  - Prevalence
MH  - Risk Factors
MH  - Time Factors
EDAT- 2002/09/25 06:00
MHDA- 2002/10/09 04:00
CRDT- 2002/09/25 06:00
PHST- 2002/09/25 06:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/09/25 06:00 [entrez]
AID - S1081-1206(10)61953-9 [pii]
AID - 10.1016/S1081-1206(10)61953-9 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2002 Sep;89(3):265-70. doi: 
      10.1016/S1081-1206(10)61953-9.