PMID- 12270036
OWN - NLM
STAT- MEDLINE
DCOM- 20021122
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 16
IP  - 4
DP  - 2002 Aug
TI  - Influences of the corticotropic axis and sympathetic activity on neurochemical 
      consequences of 3,4-methylenedioxymethamphetamine (MDMA) administration in 
      Fischer 344 rats.
PG  - 607-18
AB  - The respective influences of the corticotropic axis and sympathetic activity on 
      3,4-methylenedioxymethamphetamine (MDMA, ecstasy) immediate effects on body 
      temperature and long-term neurotoxicity, as assessed by decreases in hippocampal 
      and striatal [(3)H]5-hydroxytryptamine ([(3)H]5-HT) reuptake, [(3)H]paroxetine 
      binding at 5-HT transporters (5-HTT), and 5-HT and 5-hydroxyindoleacetic acid 
      (5-HIAA) levels, were examined in Fischer 344 rats. On each of the two injections 
      of MDMA (5 or 10 mg/kg s.c. once a day for 2 consecutive days) body temperature 
      rapidly increased in a dose-dependent manner. Six days after the last injection 
      of 10 mg/kg MDMA, [(3)H]5-HT reuptake, [(3)H]paroxetine binding and 5-HT and 
      5-HIAA levels were decreased in the hippocampus and, to a lower extent, in 
      striatum. Prior adrenalectomy (1 week beforehand), which weakened the immediate 
      hyperthermic effect of MDMA, prevented the long-term MDMA-elicited reduction in 
      hippocampal and striatal [(3)H]paroxetine binding. Supplementation of 
      adrenalectomised Fischer 344 rats with corticosterone almost reinstated the 
      immediate hyperthermic effect of MDMA and restored MDMA-elicited reduction in 
      hippocampal and striatal [(3)H]paroxetine binding. In a final set of experiments, 
      Fischer 344 rats were pretreated (30 min before each of the two injections of 10 
      mg/kg MDMA) with the ganglionic blocker chlorisondamine (2.5 mg/kg). This 
      pretreatment markedly reduced the amplitudes of the immediate hyperthermia and 
      long-term declines in hippocampal [(3)H]5-HT reuptake and [(3)H]paroxetine 
      binding at 5-HTT, and in hippocampal and striatal 5-HT and 5-HIAA levels. These 
      results suggest that sympathetic activity (possibly through its control of body 
      temperature), but not corticotropic activity, plays a key role in MDMA-elicited 
      neurotoxicity in Fischer 344 rats.
FAU - Fernandez, Francesca
AU  - Fernandez F
AD  - NeuroGenetique et Stress, INSERM U471-INRA, Institut F. Magendie, Rue Camille 
      Saint Saens, 33077 Bordeaux Cedex, France.
FAU - Aguerre, Sylvie
AU  - Aguerre S
FAU - Mormede, Pierre
AU  - Mormede P
FAU - Chaouloff, Francis
AU  - Chaouloff F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenal Cortex/*drug effects/*physiology
MH  - Adrenergic Fibers/*drug effects/metabolism/*physiology
MH  - Animals
MH  - Body Temperature/drug effects/physiology
MH  - Corpus Striatum/drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Hypothalamo-Hypophyseal System/drug effects/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Pituitary-Adrenal System/drug effects/metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin/metabolism
EDAT- 2002/09/25 06:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/25 06:00
PHST- 2002/09/25 06:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/25 06:00 [entrez]
AID - 2110 [pii]
AID - 10.1046/j.1460-9568.2002.02110.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2002 Aug;16(4):607-18. doi: 10.1046/j.1460-9568.2002.02110.x.