PMID- 12270646
OWN - NLM
STAT- MEDLINE
DCOM- 20021213
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 330
IP  - 3
DP  - 2002 Sep 27
TI  - Rewarding effects of the optical isomers of 3,4-methylenedioxy-methylamphetamine 
      ('Ecstasy') and 3,4-methylenedioxy-ethylamphetamine ('Eve') measured by 
      conditioned place preference in rats.
PG  - 280-4
AB  - 3,4-methylenedioxy-methylamphetamine (MDMA) ('Ecstasy') and its analogue 
      3,4-methylenedioxy-methylamphetamine (MDE) ('Eve') are well known illicit street 
      drugs mainly abused by young people. In spite of the actual research going on, 
      the classification of their abuse potential remains unclear. Since secondary 
      reinforcers are the main factors responsible for craving and relapse, the aim of 
      our study was to assess the potency of MDMA and MDE in a second order 
      reinforcement paradigm, i.e. conditioned place preference (CPP). For the general 
      assessment of our study conditions, we compared MDMA with amphetamine. 
      Unexpectedly, no significant CPP for MDMA was found in contrast to amphetamine. 
      Detailed analysis of current literature led us to the working hypothesis that 
      social environment is crucial for the development of CPP. In a subsequent 
      experiment we tested the influence of housing conditions on CPP using MDMA and 
      demonstrated that isolated animals show significant CPP compared to group-housed 
      ones. In order to better understand the rewarding mechanisms of 
      Ecstasy-derivatives, we tested both the racemic drugs and the pure isomers in the 
      CPP paradigm. Both MDMA's optical isomers and racemic MDMA showed significant CPP 
      without notable differences, while MDE and its isomers completely failed to show 
      any significant CPP. In conclusion, the mechanism by which MDMA induces addiction 
      is much more complicated than assumed so far and more pronounced in isolated 
      animals. The fact that both optical isomers of MDMA led to CPP implies that at 
      least two pathways by which MDMA induces craving behaviour exist.
CI  - Copyright 2002 Elsevier Science Ltd.
FAU - Meyer, Anja
AU  - Meyer A
AD  - Institute of Pharmacy, University of Tubingen, Tubingen, Germany.
FAU - Mayerhofer, Andreas
AU  - Mayerhofer A
FAU - Kovar, Karl-Artur
AU  - Kovar KA
FAU - Schmidt, Werner J
AU  - Schmidt WJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*pharmacology
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Central Nervous System Stimulants/pharmacology
MH  - Choice Behavior/*drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Hallucinogens/*pharmacology
MH  - Isomerism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reward
MH  - Social Isolation
EDAT- 2002/09/25 06:00
MHDA- 2002/12/17 04:00
CRDT- 2002/09/25 06:00
PHST- 2002/09/25 06:00 [pubmed]
PHST- 2002/12/17 04:00 [medline]
PHST- 2002/09/25 06:00 [entrez]
AID - S0304394002008212 [pii]
AID - 10.1016/s0304-3940(02)00821-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Sep 27;330(3):280-4. doi: 10.1016/s0304-3940(02)00821-2.