PMID- 12270736
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 24
IP  - 2
DP  - 2002 Oct
TI  - Differential effect of cytotoxic T lymphocyte variant epitopes on generation and 
      cytotoxicity in chronic hepatitis C virus infection.
PG  - 91
AB  - Human leukocyte antigen (HLA) B44-restricted, hepatitis C virus (HCV)-specific 
      cytotoxic T lymphocytes (CTLs) recognize HCV nucleoprotein amino acid residues 
      88-96 as an epitope. We previously reported the existence of variant peptide 
      sequences at the epitope locus in three of 27 patients with HCV infection and HLA 
      B44. Here we studied the effects of the variant peptide sequences on generation 
      and cytotoxicity of CTLs. Two of the three variant peptides generated CTLs poorly 
      although they activated well the cytotoxicity of CTLs. Such a differential 
      activation of proliferation and cytotoxicity may contribute to the emergence of 
      HCV with variant epitopes for CTLs.
FAU - Hiroishi, Kazumasa
AU  - Hiroishi K
AD  - Second Department of Internal Medicine, Showa University School of Medicine, 
      1-5-8 Hatanodai, Shinagawa-ku, 142-8666, Tokyo, Japan
FAU - Eguchi, Jun
AU  - Eguchi J
FAU - Ishii, Shigeaki
AU  - Ishii S
FAU - Okamoto, Hiroaki
AU  - Okamoto H
FAU - Mitamura, Keiji
AU  - Mitamura K
FAU - Imawari, Michio
AU  - Imawari M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
EDAT- 2002/09/25 06:00
MHDA- 2002/09/25 06:01
CRDT- 2002/09/25 06:00
PHST- 2002/09/25 06:00 [pubmed]
PHST- 2002/09/25 06:01 [medline]
PHST- 2002/09/25 06:00 [entrez]
AID - S1386634602000785 [pii]
AID - 10.1016/s1386-6346(02)00078-5 [doi]
PST - ppublish
SO  - Hepatol Res. 2002 Oct;24(2):91. doi: 10.1016/s1386-6346(02)00078-5.