PMID- 12297419
OWN - NLM
STAT- MEDLINE
DCOM- 20021112
LR  - 20191106
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 23
IP  - 10
DP  - 2002 Oct
TI  - Immune escape through C-type lectins on dendritic cells.
PG  - 480-5
AB  - Dendritic cells (DCs) detect different pathogens and elicit tailored 
      anti-microbial immune responses. They express C-type lectins that recognise 
      carbohydrate profiles on microorganisms, resulting in internalisation, processing 
      and presentation. Intracellular sequences of distinct DC-specific lectins point 
      to differences in intracellular routing that influence antigen presentation. 
      Moreover, putative signalling motifs hint to the activation of DCs on 
      carbohydrate recognition. Recent evidence shows that not only pathogens, but also 
      tumour antigens, exploit C-type lectins to escape intracellular degradation 
      resulting in abortive immunity. More insight into ligand specificity, 
      intracellular targeting and signalling will reveal the pathways by which 
      pathogens modulate immunity through C-type lectins.
FAU - Engering, Anneke
AU  - Engering A
AD  - Dept. of Molecular Cell Biology, VU Medical Center, van der Boechorststraat 7, 
      1081 BT, Amsterdam, The Netherlands.
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Carbohydrates)
RN  - 0 (Lectins)
RN  - 0 (Ligands)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Carbohydrates/immunology
MH  - Dendritic Cells/*immunology
MH  - HIV Infections/immunology/virology
MH  - Humans
MH  - Immunity, Cellular
MH  - Lectins/classification/*immunology
MH  - Ligands
MH  - Neoplasms/immunology
RF  - 47
EDAT- 2002/09/26 06:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/26 06:00
PHST- 2002/09/26 06:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/26 06:00 [entrez]
AID - S1471490602022962 [pii]
AID - 10.1016/s1471-4906(02)02296-2 [doi]
PST - ppublish
SO  - Trends Immunol. 2002 Oct;23(10):480-5. doi: 10.1016/s1471-4906(02)02296-2.