PMID- 1230483
OWN - NLM
STAT- MEDLINE
DCOM- 19760925
LR  - 20131121
IS  - 0368-2315 (Print)
IS  - 0150-9918 (Linking)
VI  - 4
IP  - 2
DP  - 1975 Mar
TI  - [Estroprogestational drugs and the ultimate embyogenesis in the rat].
PG  - 183-91
AB  - Cyclic female rats were fed with ethinodiol diacetate plus mestranol (EDM) for 
      periods of 45 to 180 days. They were mated during prooestrus, on the first cycle 
      following the end of the treatment. Results were as follows: 1. The cycle is 
      blocked about eight days after starting E.D.M. The longer the treatment, the 
      later rats resume their cycle. 2. Degeneration of the ova before implantation and 
      embryonic mortality are slightly augmented when fecundation takes place within 
      two days after stopping E.D.M.; whereas from the third cycle on, the quality of 
      th ova is identical to the control group. The ova are euploid; they are more 
      fragile to hypotonic shock than the ova of the control animals. No influence of 
      E.D.M. upon meiotic or mitotic processes could be demonstrated. Those experiments 
      do no allow any inference to the human species, but they are inkeeping with the 
      observations of Boue et al. on women.
FAU - Plachot, M
AU  - Plachot M
FAU - Netter, A
AU  - Netter A
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Oestroprogestatifs et embryogenese ulterieure chez la ratte.
PL  - France
TA  - J Gynecol Obstet Biol Reprod (Paris)
JT  - Journal de gynecologie, obstetrique et biologie de la reproduction
JID - 0322206
RN  - 0 (Hypotonic Solutions)
RN  - 62H10A1236 (Ethynodiol Diacetate)
SB  - IM
MH  - Animals
MH  - Embryo, Mammalian/drug effects
MH  - Estrus/drug effects
MH  - Ethynodiol Diacetate/*pharmacology
MH  - Female
MH  - Hypotonic Solutions
MH  - Ovum/drug effects
MH  - Pregnancy/*drug effects
MH  - Rats
MH  - Vaginal Smears
EDAT- 1975/03/01 00:00
MHDA- 1975/03/01 00:01
CRDT- 1975/03/01 00:00
PHST- 1975/03/01 00:00 [pubmed]
PHST- 1975/03/01 00:01 [medline]
PHST- 1975/03/01 00:00 [entrez]
PST - ppublish
SO  - J Gynecol Obstet Biol Reprod (Paris). 1975 Mar;4(2):183-91.