PMID- 12322894
OWN - NLM
STAT- MEDLINE
DCOM- 20030129
LR  - 20190922
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 48
IP  - 1
DP  - 2002 Jul
TI  - Possible roles for products of polymorphic MHC and linked olfactory receptor 
      genes during selection processes in reproduction.
PG  - 34-42
AB  - PROBLEM: Polymorphic genes of the human major histocompatibility complex [MHC; 
      human leukocyte antigen (HLA)] are probably important in determining resistance 
      to parasites and avoidance of inbreeding. We investigated whether HLA-associated 
      sexual selection could also involve HLA-linked olfactory receptor (OR) genes, 
      which might not only participate in olfaction-guided mate choice, but also in 
      selection processes within the testis. METHOD OF STUDY: The testicular expression 
      status of HLA class I molecules (by immunohistology) and HLA-linked OR genes (by 
      transcriptional analysis) was determined. RESULTS: Various HLA class I heavy 
      chains, but not beta2-microglobulin (beta2m), were expressed, mainly at the 
      spermatocyte I stage. Of 17 HLA-linked OR genes analyzed, eight were found to be 
      transcribed in the testis. They exhibited varying numbers of 5'- or 3'-non-coding 
      exons as well as differential splicing. CONCLUSIONS: We suggest that 
      testis-expressed polymorphic HLA and OR proteins are functionally connected and 
      serve the selection of spermatozoa, enabling them to distinguish 'self from 
      'non-self [the sperm-receptor-selection (SRS) hypothesis].
FAU - Ziegler, Andreas
AU  - Ziegler A
AD  - Institut fur Immungenetik, Universitatsklinikum Charite, Humboldt-Universitat zu 
      Berlin, Germany. andreas.ziegler@charite.de
FAU - Dohr, Gotrfried
AU  - Dohr G
FAU - Uchanska-Ziegler, Barbara
AU  - Uchanska-Ziegler B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Receptors, Odorant)
SB  - IM
MH  - Epithelium/metabolism
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics/physiology
MH  - Male
MH  - Receptors, Odorant/*genetics/metabolism
MH  - Reproduction/*genetics
MH  - Sertoli Cells/metabolism
MH  - Spermatozoa/metabolism
MH  - Testis/metabolism
EDAT- 2002/09/27 06:00
MHDA- 2003/01/30 04:00
CRDT- 2002/09/27 06:00
PHST- 2002/09/27 06:00 [pubmed]
PHST- 2003/01/30 04:00 [medline]
PHST- 2002/09/27 06:00 [entrez]
AID - 10.1034/j.1600-0897.2002.01097.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2002 Jul;48(1):34-42. doi: 10.1034/j.1600-0897.2002.01097.x.