PMID- 12324743
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20190916
IS  - 0022-5223 (Print)
IS  - 0022-5223 (Linking)
VI  - 124
IP  - 4
DP  - 2002 Oct
TI  - Synovial sarcoma of the pleura: a clinical and pathologic study of three cases.
PG  - 828-32
AB  - Synovial sarcomas are rare soft tissue malignancies that most commonly affect the 
      extremities in the vicinity of large joints. These malignancies typically occur 
      in adolescents and young adults between the ages of 15 and 40 years.(1,2) 
      Historically they are believed to originate from primitive pluripotent mesenchyme 
      capable of synovial differentiation. This belief is consistent with the 
      malignancy's origin from sites devoid of normal synovium, such as the pleural 
      cavity. A variety of pleural cavity sarcomas have been described, including 
      liposarcoma,(3) chondrosarcoma,(4) osteosarcoma,(5) and malignant schwannoma.(6) 
      Pleural synovial sarcoma, however, is a much rarer entity. In fact, pleural 
      synovial sarcoma was first described only 6 years ago(7) and has not yet been 
      reported in the surgical literature. Because of its rarity, pleural synovial 
      sarcoma is often mistaken for the histologically similar malignant mesothelioma, 
      the most common of the pleural neoplasms. This is a critical distinction, because 
      synovial sarcoma may be extremely aggressive. Studies in the last 10 years have 
      shown it to be extremely sensitive to ifosfamide-based chemotherapy, and survival 
      of patients with synovial sarcoma has recently increased with chemotherapy, with 
      5-year survivals now as high as 57%.(8-10) In this report, we describe 3 cases of 
      synovial sarcoma of the pleura. Clinical findings are correlated with pathologic 
      features, including immunohistochemical stains and fluorescence in situ 
      hybridization (FISH) for the identification of the diagnostic chromosomal 
      translocation, t(X;18)(p11.2;q11.2). This delineation of the clinical and 
      pathologic aspects of this rare, newly recognized tumor should increase awareness 
      among the surgical community.
FAU - Colwell, Amy S
AU  - Colwell AS
AD  - Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
FAU - D'Cunha, Jonathan
AU  - D'Cunha J
FAU - Vargas, Sara O
AU  - Vargas SO
FAU - Parker, Benjamin
AU  - Parker B
FAU - Dal Cin, Paola
AU  - Dal Cin P
FAU - Maddaus, Michael A
AU  - Maddaus MA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
SB  - IM
MH  - Adult
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Pleural Neoplasms/diagnostic imaging/*pathology/surgery
MH  - Sarcoma, Synovial/diagnostic imaging/*pathology/surgery
MH  - Tomography, X-Ray Computed
EDAT- 2002/09/27 06:00
MHDA- 2002/12/10 04:00
CRDT- 2002/09/27 06:00
PHST- 2002/09/27 06:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/09/27 06:00 [entrez]
AID - S0022522302001575 [pii]
AID - 10.1067/mtc.2002.124242 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2002 Oct;124(4):828-32. doi: 10.1067/mtc.2002.124242.