PMID- 12324849
OWN - NLM
STAT- MEDLINE
DCOM- 20021112
LR  - 20191210
IS  - 1618-2642 (Print)
IS  - 1618-2642 (Linking)
VI  - 374
IP  - 2
DP  - 2002 Sep
TI  - Impurity profiling of seized MDMA tablets by capillary gas chromatography.
PG  - 274-81
AB  - Impurity profiles of 3,4-methylenedioxymethylamphetamine (MDMA) tablets seized in 
      France have been examined. The samples were extracted with methylene chloride 
      under basic conditions and then analyzed by capillary gas chromatography. Almost 
      30 compounds were identified as precursors, intermediates and by-products. 
      Palmitic and stearic acid were also found as tableting materials. The comparison 
      of the different profiles obtained by the reported procedure provided very useful 
      information about the synthetic processes used by clandestine laboratories and 
      enabled a classification into several groups of profiles. According to these 
      results, the reductive amination route appears to be the most common synthetic 
      pathway in Western Europe. Furthermore, 3,4-methylenedioxyphenyl-2-propanone 
      seems to be the most used precursor in clandestine laboratories.
FAU - Palhol, Fabien
AU  - Palhol F
AD  - Laboratoire d'Analyse Isotopique et Electrochimique de Metabolismes, UMR 6006, 
      Faculte des Sciences, 2 rue de la Houssiniere, 44322 Nantes, France. 
      fpalhol@wanadoo.fr
FAU - Boyer, Sophie
AU  - Boyer S
FAU - Naulet, Norbert
AU  - Naulet N
FAU - Chabrillat, Martine
AU  - Chabrillat M
LA  - eng
PT  - Journal Article
DEP - 20020828
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - 0 (Tablets)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Chromatography, Gas/*methods
MH  - Drug Contamination
MH  - Hallucinogens/*analysis
MH  - Illicit Drugs/*analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Reproducibility of Results
MH  - Tablets
EDAT- 2002/09/27 06:00
MHDA- 2002/11/26 04:00
CRDT- 2002/09/27 06:00
PHST- 2002/06/03 00:00 [received]
PHST- 2002/07/02 00:00 [revised]
PHST- 2002/07/03 00:00 [accepted]
PHST- 2002/09/27 06:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/09/27 06:00 [entrez]
AID - 10.1007/s00216-002-1477-6 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2002 Sep;374(2):274-81. doi: 10.1007/s00216-002-1477-6. Epub 
      2002 Aug 28.