PMID- 12350245
OWN - NLM
STAT- MEDLINE
DCOM- 20051020
LR  - 20191106
IS  - 1521-737X (Print)
IS  - 1521-737X (Linking)
VI  - 4
IP  - 5
DP  - 2002 Sep-Oct
TI  - Tinzaparin.
PG  - 331-40
AB  - Low-molecular-weight heparins (LMWH) are efficacious agents that offer clinical 
      and pharmacoeconomic advantages over unfractionated heparin (UFH) for the 
      treatment of ACS and venous thromboembolism. Tinzaparin is a LMWH approved for 
      the treatment of deep venous thrombosis with and without pulmonary embolism, when 
      used in conjunction with warfarin. In studies with hospitalized patients who had 
      deep venous thrombosis or pulmonary embolism, tinzaparin was at least as 
      efficacious as UFH, with fewer adverse bleeding events. It is also efficacious 
      for thromboembolic prophylaxis in patients undergoing general and orthopedic 
      surgery. Studies have shown that tinzaparin is at least as effective as UFH for 
      patients undergoing surgery and in other patients at risk for developing 
      thromboembolism. It is currently not recommended for use in patients with 
      ischemic strokes. There are minimal data available regarding its use in the 
      management of patients with unstable angina (UA) and non-ST-segment elevation 
      myocardial infarction.
FAU - Wong, Nina N
AU  - Wong NN
AD  - Department of Pharmacy and Family Medicine, Montefiore Medical Center, Bronx, New 
      York 10467, USA. nwong@montefiore.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Heart Dis
JT  - Heart disease (Hagerstown, Md.)
JID - 100887299
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 7UQ7X4Y489 (Tinzaparin)
SB  - IM
MH  - Angina, Unstable/drug therapy
MH  - Drug Interactions
MH  - Fibrinolytic Agents/chemistry/economics/*pharmacology
MH  - Heparin, Low-Molecular-Weight/chemistry/economics/*pharmacology
MH  - Humans
MH  - Molecular Structure
MH  - Myocardial Infarction/drug therapy
MH  - Stroke/drug therapy
MH  - Tinzaparin
MH  - Venous Thrombosis/drug therapy/prevention & control
RF  - 58
EDAT- 2002/09/28 04:00
MHDA- 2005/10/21 09:00
CRDT- 2002/09/28 04:00
PHST- 2002/09/28 04:00 [pubmed]
PHST- 2005/10/21 09:00 [medline]
PHST- 2002/09/28 04:00 [entrez]
AID - 10.1097/00132580-200209000-00009 [doi]
PST - ppublish
SO  - Heart Dis. 2002 Sep-Oct;4(5):331-40. doi: 10.1097/00132580-200209000-00009.