PMID- 12350299
OWN - NLM
STAT- MEDLINE
DCOM- 20030102
LR  - 20190901
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 130 Suppl
DP  - 2002 Sep 14
TI  - From physiology to pathology: arousal deficiency theory in sudden infant death 
      syndrome (SIDS)--with reference to apoptosis and neuronal plasticity.
PG  - S37-43
AB  - Among 27,000 infants studied prospectively to characterize their sleep-wake 
      behavior, 38 infants died under 6 months of age (including 26 infant victims of 
      sudden infant death syndrome (SIDS), 5 with congenital cardiac abnormalities, 2 
      from infected pulmonary dysplasia, 2 from septic shock with multi-organ failure, 
      1 with a prolonged seizure, 1 from prolonged neonatal hypoxemia, 1 from 
      meningitis and brain infarction). The frequency and duration of sleep apneas 
      recorded some 3-12 weeks before the infants' death were analyzed. Brainstem 
      material from these 38 infants was studied in an attempt to elucidate the 
      relationship between sleep apnea and neuronal pathological changes in the arousal 
      pathway. Immunohistochemical analyses included the evaluation of 
      growth-associated phosphoprotein 43 (GAP43) as a marker for synaptic plasticity. 
      The terminal-deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      method was used to identify apoptosis. The positive pathological reactions were 
      quantitatively analyzed. The pathological and physiological data were linked for 
      each infant. Akaike Information Criterion (AIC) statistics was calculated to 
      elucidate the relationship between the physiological and the pathological data in 
      the SIDS victims. The findings illustrated the possibility of an organic 
      fragility within the arousal pathway, particularly in the midbrain periaqueductal 
      gray matter, which is associated with the "visceral alerting response". This 
      autonomic response occurs within an acetylcholine afferent system and 
      pedunculopontine tegmental nucleus (PPTN). The finding is, in future SIDS 
      infants, associated with repetitive sleep apnea.
FAU - Sawaguchi, Toshiko
AU  - Sawaguchi T
AD  - Department of Legal Medicine, Tokyo Women's Medical University School of 
      Medicine, 8-1 Kawada-cho, Shinjuku, Tokyo 162-8666, Japan. 
      tsawagu@research.twmu.ac.jp
FAU - Franco, Patricia
AU  - Franco P
FAU - Kato, Ineko
AU  - Kato I
FAU - Shimizu, Satoru
AU  - Shimizu S
FAU - Kadhim, Hazim
AU  - Kadhim H
FAU - Groswasser, Jose
AU  - Groswasser J
FAU - Sottiaux, Martine
AU  - Sottiaux M
FAU - Togari, Hajime
AU  - Togari H
FAU - Kobayashi, Makio
AU  - Kobayashi M
FAU - Takashima, Sachio
AU  - Takashima S
FAU - Nishida, Hiroshi
AU  - Nishida H
FAU - Sawaguchi, Akiko
AU  - Sawaguchi A
FAU - Kahn, Andre
AU  - Kahn A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (GAP-43 Protein)
SB  - IM
MH  - *Apoptosis
MH  - Autonomic Pathways/pathology
MH  - Brain Stem/pathology
MH  - GAP-43 Protein/metabolism
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - Infant
MH  - *Neuronal Plasticity
MH  - Polysomnography
MH  - Prospective Studies
MH  - Sleep Apnea, Obstructive/pathology
MH  - Sleep Arousal Disorders/*pathology
MH  - Sudden Infant Death/*pathology
EDAT- 2002/09/28 04:00
MHDA- 2003/01/03 04:00
CRDT- 2002/09/28 04:00
PHST- 2002/09/28 04:00 [pubmed]
PHST- 2003/01/03 04:00 [medline]
PHST- 2002/09/28 04:00 [entrez]
AID - S0379073802001366 [pii]
AID - 10.1016/s0379-0738(02)00136-6 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2002 Sep 14;130 Suppl:S37-43. doi: 
      10.1016/s0379-0738(02)00136-6.