PMID- 12351485
OWN - NLM
STAT- MEDLINE
DCOM- 20030331
LR  - 20190515
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 25
IP  - 10
DP  - 2002 Oct
TI  - Increased plasma-soluble tumor necrosis factor-alpha receptor 2 level in lean 
      nondiabetic offspring of type 2 diabetic subjects.
PG  - 1824-8
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is one of the proposed 
      mediators of insulin resistance, upregulated in human obesity. Insulin 
      resistance, however, might precede the development of obesity, especially in 
      subjects with a family history of type 2 diabetes. Therefore, the aim of the 
      present study was to assess plasma levels of TNF-alpha and soluble forms of its 
      receptors (soluble TNF-alpha receptors 1 [sTNFR1] and 2 [sTNFR2]) and to evaluate 
      the relationship of the TNF-alpha system with insulin resistance in lean, 
      nondiabetic offspring of type 2 diabetic patients. RESEARCH DESIGN AND METHODS: 
      We compared 20 lean offspring (BMI <25 kg/m(2), 8 men and 12 women) of type 2 
      diabetic patients with 20 lean subjects with no family history of diabetes, 
      matched for age, sex, and BMI (control group). Anthropometry and blood 
      biochemical parameters were measured, and insulin sensitivity was evaluated with 
      the euglycemic-hyperinsulinemic clamp technique. RESULTS: Both men and women in 
      the offspring group were markedly more insulin-resistant and had higher plasma 
      levels of sTNFR2 (all P < 0.05). TNF-alpha, sTNFR1, and other examined parameters 
      did not differ between the studied groups. Both TNF-alpha receptors were related 
      to waist-to-hip ratio (WHR), fat-free mass (FFM), plasma total cholesterol, HDL 
      cholesterol, LDL cholesterol, and nonesterified fatty acids (NEFAs). sTNFR2, but 
      not sTNFR1, was also associated with insulin sensitivity (r = -0.49, P = 0.001). 
      This relationship remained significant after adjustment for WHR, FFM, plasma 
      insulin, and NEFA. CONCLUSIONS: TNF-alpha system might be involved in modulating 
      insulin action before the onset of obesity in subjects at high risk for type 2 
      diabetes.
FAU - Straczkowski, Marek
AU  - Straczkowski M
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical Academy, 
      Bialystok, Poland. mstraczkowski@poczta.onet.pl
FAU - Kowalska, Irina
AU  - Kowalska I
FAU - Stepien, Agnieszka
AU  - Stepien A
FAU - Dzienis-Straczkowska, Stella
AU  - Dzienis-Straczkowska S
FAU - Szelachowska, Malgorzata
AU  - Szelachowska M
FAU - Kinalska, Ida
AU  - Kinalska I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Antigens, CD)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
SB  - IM
MH  - Adipose Tissue/anatomy & histology
MH  - Adult
MH  - Antigens, CD/*blood
MH  - Body Mass Index
MH  - Body Weight
MH  - Diabetes Mellitus/blood/immunology
MH  - Diabetes Mellitus, Type 2/blood/*genetics/*immunology
MH  - Female
MH  - Humans
MH  - Insulin Resistance/immunology
MH  - Male
MH  - Nuclear Family
MH  - Obesity
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Reference Values
MH  - Regression Analysis
EDAT- 2002/09/28 04:00
MHDA- 2003/04/01 05:00
CRDT- 2002/09/28 04:00
PHST- 2002/09/28 04:00 [pubmed]
PHST- 2003/04/01 05:00 [medline]
PHST- 2002/09/28 04:00 [entrez]
AID - 10.2337/diacare.25.10.1824 [doi]
PST - ppublish
SO  - Diabetes Care. 2002 Oct;25(10):1824-8. doi: 10.2337/diacare.25.10.1824.