PMID- 12352591
OWN - NLM
STAT- MEDLINE
DCOM- 20030505
LR  - 20190906
IS  - 0143-3636 (Print)
IS  - 0143-3636 (Linking)
VI  - 23
IP  - 10
DP  - 2002 Oct
TI  - Prognosis of hibernating myocardium is independent of recovery of function: 
      evidence from a routine based follow-up study.
PG  - 933-42
AB  - Revascularization of hibernating segments improves both ventricular function (VF) 
      and survival. In this study, we determined whether this relation is true in a 
      routine based patients population with mildly reduced VF. Two to 6 years after 
      undergoing 201Tl scintigraphy to detect hibernation, 153 patients were 
      interviewed in order to collect medical information. This population was divided 
      into four groups, according to the presence or absence of myocardial hibernation 
      and of revascularization. Age, gender and left ventricular ejection fraction 
      (LVEF) were similar in the four groups. Hard cardiac events (HEs) were noted in 
      14/33 (41%) patients with uncorrected hibernation, while in the other three 
      groups HEs were recorded in fewer than 3% of patients. Univariate analysis 
      indicated that the presence of hibernation, regardless of its extension, was the 
      highest significant predictor of HEs. Multivariate analysis indicated that 
      hibernation, stress ischaemia, age and absence of revascularization were 
      significant predictors of HEs. These findings were not related to changes in LVEF 
      or to New York Heart Association (NYHA) class during follow-up. In this routine 
      based patient population, with mildly reduced VF, the rate of HEs seems to be 
      related to uncorrected hibernation regardless of its extension. In these patients 
      revascularization of hibernating segments is effective in reducing the risk of 
      HEs while its role in improving VF or NYHA class is negligible.
CI  - Copyright 2002 Lippincott Williams & Wilkins
FAU - Podio, V
AU  - Podio V
AD  - Department of Nuclear Medicine, University of Turin, Turin, Italy. 
      valerio.podio@unito.it
FAU - Spinnler, M T
AU  - Spinnler MT
FAU - Bertuccio, G
AU  - Bertuccio G
FAU - Carbonero, C
AU  - Carbonero C
FAU - Pelosi, E
AU  - Pelosi E
FAU - Bisi, G
AU  - Bisi G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Revascularization
MH  - Myocardial Stunning/*diagnostic imaging/*therapy
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Radionuclide Imaging
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Survival Analysis
MH  - Thallium
MH  - Ventricular Function, Left
EDAT- 2002/09/28 04:00
MHDA- 2003/05/06 05:00
CRDT- 2002/09/28 04:00
PHST- 2002/09/28 04:00 [pubmed]
PHST- 2003/05/06 05:00 [medline]
PHST- 2002/09/28 04:00 [entrez]
AID - 10.1097/00006231-200210000-00002 [doi]
PST - ppublish
SO  - Nucl Med Commun. 2002 Oct;23(10):933-42. doi: 10.1097/00006231-200210000-00002.