PMID- 12353808
OWN - NLM
STAT- MEDLINE
DCOM- 20030129
LR  - 20190906
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 75
IP  - 3
DP  - 2002 Oct
TI  - Origin and progression of pregnancy-dependent mammary tumors induced by new mouse 
      mammary tumor virus variants.
PG  - 191-202
AB  - In order to study mechanisms of progression of mouse mammary tumor virus 
      (MMTV)-induced pregnancy-dependent mammary lesions, we removed and serially 
      transplanted 17 small tumors detected in MMTV-infected pregnant females. This 
      gave rise to the same number of 'in vivo' tumor lines. Hormone-dependency of the 
      passages was determined by comparing tumor development in multiparous versus 
      virgin hosts. We found that the first passages of most of these lesions (11/17) 
      required pregnancy to grow. However, all these tumor lines lost their 
      hormone-dependence through successive passages. The original pregnancy-dependent 
      lesions were mostly multiclonal and showed high levels of estrogen and 
      progesterone receptors. Alternatively, pregnancy-independent tumors arose as 
      clonal dominant populations exhibiting a lower hormone receptor content. Our data 
      show that the progression of hormone-dependent MMTV-induced mammary tumors is an 
      irreversible process associated with the appearance of additional MMTV 
      insertional events as well as alterations in the composition of the tumor cell 
      population.
FAU - Buggiano, Valeria
AU  - Buggiano V
AD  - ILEX-CONICET, Division de Medicina Experimental, Instituto de Investigaciones 
      Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
FAU - Levy, Carolina Schere
AU  - Levy CS
FAU - Gattelli, Albana
AU  - Gattelli A
FAU - Cirio, Maria Cecilia
AU  - Cirio MC
FAU - Marfil, Mariana
AU  - Marfil M
FAU - Nepomnaschy, Irene
AU  - Nepomnaschy I
FAU - Piazzon, Isabel
AU  - Piazzon I
FAU - Helguero, Luisa
AU  - Helguero L
FAU - Vanzulli, Silvia
AU  - Vanzulli S
FAU - Kordon, Edith C
AU  - Kordon EC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - DNA, Neoplasm/metabolism
MH  - Disease Progression
MH  - Estrogens/metabolism
MH  - Female
MH  - Mammary Neoplasms, Experimental/metabolism/pathology/*virology
MH  - Mammary Tumor Virus, Mouse/*pathogenicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasm Transplantation
MH  - Neoplasms, Hormone-Dependent/metabolism/pathology/*virology
MH  - Pregnancy
MH  - *Pregnancy, Animal
MH  - Progesterone/metabolism
MH  - Receptors, Estrogen/metabolism
MH  - Receptors, Progesterone/metabolism
EDAT- 2002/10/02 04:00
MHDA- 2003/01/30 04:00
CRDT- 2002/10/02 04:00
PHST- 2002/10/02 04:00 [pubmed]
PHST- 2003/01/30 04:00 [medline]
PHST- 2002/10/02 04:00 [entrez]
AID - 10.1023/a:1019932516887 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2002 Oct;75(3):191-202. doi: 10.1023/a:1019932516887.