PMID- 12354396
OWN - NLM
STAT- MEDLINE
DCOM- 20021022
LR  - 20220309
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 35
IP  - 6
DP  - 2002 Sep 12
TI  - A divergent pattern of sensory axonal projections is rendered convergent by 
      second-order neurons in the accessory olfactory bulb.
PG  - 1057-66
AB  - The mammalian vomeronasal system is specialized in pheromone detection. The 
      neural circuitry of the accessory olfactory bulb (AOB) provides an anatomical 
      substrate for the coding of pheromone information. Here, we describe the axonal 
      projection pattern of vomeronasal sensory neurons to the AOB and the dendritic 
      connectivity pattern of second-order neurons. Genetically traced sensory neurons 
      expressing a given gene of the V2R class of vomeronasal receptors project their 
      axons to six to ten glomeruli distributed in globally conserved areas of the AOB, 
      a theme similar to V1R-expressing neurons. Surprisingly, second-order neurons 
      tend to project their dendrites to glomeruli innervated by axons of sensory 
      neurons expressing the same V1R or the same V2R gene. Convergence of receptor 
      type information in the olfactory bulb may represent a common design in olfactory 
      systems.
FAU - Del Punta, Karina
AU  - Del Punta K
AD  - The Rockefeller University, New York, NY 10021, USA.
FAU - Puche, Adam
AU  - Puche A
FAU - Adams, Niels C
AU  - Adams NC
FAU - Rodriguez, Ivan
AU  - Rodriguez I
FAU - Mombaerts, Peter
AU  - Mombaerts P
LA  - eng
GR  - DC000347/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Luminescent Proteins)
RN  - 0 (Pheromones)
RN  - 0 (Receptors, Cell Surface)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Animals
MH  - Axons/metabolism/*ultrastructure
MH  - Chemoreceptor Cells/cytology/metabolism
MH  - Chimera
MH  - Dendrites/metabolism/*ultrastructure
MH  - Green Fluorescent Proteins
MH  - Luminescent Proteins
MH  - Mice
MH  - Mice, Transgenic
MH  - Neural Pathways/*cytology/metabolism
MH  - Neurons, Afferent/*cytology/metabolism
MH  - Olfactory Bulb/*cytology/metabolism
MH  - Pheromones/physiology
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Synapses/metabolism/ultrastructure
MH  - Vomeronasal Organ/*cytology/metabolism
EDAT- 2002/10/02 04:00
MHDA- 2002/10/31 04:00
CRDT- 2002/10/02 04:00
PHST- 2002/10/02 04:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/10/02 04:00 [entrez]
AID - S0896627302009042 [pii]
AID - 10.1016/s0896-6273(02)00904-2 [doi]
PST - ppublish
SO  - Neuron. 2002 Sep 12;35(6):1057-66. doi: 10.1016/s0896-6273(02)00904-2.