PMID- 12355385
OWN - NLM
STAT- MEDLINE
DCOM- 20021016
LR  - 20061115
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 35
IP  - 8
DP  - 2002 Oct 15
TI  - The pathogenesis of hepatitis C virus is influenced by cytomegalovirus.
PG  - 974-81
AB  - We investigated the effect of beta-herpesviruses on allograft failure and 
      mortality, hepatitis C virus (HCV) replication, and liver histologic 
      characteristics among 92 HCV-infected liver transplant recipients. Reactivation 
      of cytomegalovirus (CMV) but not of human herpesvirus 6 (HHV-6) was independently 
      associated with allograft failure and mortality (risk ratio, 3.71; 95% confidence 
      interval, 1.64-8.39); allograft failure and mortality was observed in 48% of 
      patients with CMV disease, 35% of patients with subclinical CMV infection, and 
      17% of patients without CMV infection (P=.0275). CMV reactivation was highly 
      predictive of mortality (P<.001), regardless of whether it remained subclinical 
      or evolved into CMV disease. Patients with CMV disease had a higher fibrosis 
      stage (P=.05) and had a trend toward a higher hepatitis activity index (P=.10) 
      and HCV load (P=.10) at 16 weeks after liver transplantation. The pathogenesis of 
      HCV is influenced by its interaction with CMV but not with HHV-6.
FAU - Razonable, Raymund R
AU  - Razonable RR
AD  - Division of Infectious Diseases and Internal Medicine, Mayo Clinic and 
      Foundation, Rochester, MN 55905, USA.
FAU - Burak, Kelly W
AU  - Burak KW
FAU - van Cruijsen, Hester
AU  - van Cruijsen H
FAU - Brown, Robert A
AU  - Brown RA
FAU - Charlton, Michael R
AU  - Charlton MR
FAU - Smith, Thomas F
AU  - Smith TF
FAU - Espy, Mark J
AU  - Espy MJ
FAU - Kremers, Walter
AU  - Kremers W
FAU - Wilson, Jennie A
AU  - Wilson JA
FAU - Groettum, Cynthia
AU  - Groettum C
FAU - Wiesner, Russell
AU  - Wiesner R
FAU - Paya, Carlos V
AU  - Paya CV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020926
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cytomegalovirus/*physiology
MH  - Female
MH  - Hepacivirus/*pathogenicity/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Viral Interference
MH  - Virus Replication
EDAT- 2002/10/02 04:00
MHDA- 2002/10/17 04:00
CRDT- 2002/10/02 04:00
PHST- 2002/03/04 00:00 [received]
PHST- 2002/06/24 00:00 [revised]
PHST- 2002/10/02 04:00 [pubmed]
PHST- 2002/10/17 04:00 [medline]
PHST- 2002/10/02 04:00 [entrez]
AID - CID020334 [pii]
AID - 10.1086/342911 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2002 Oct 15;35(8):974-81. doi: 10.1086/342911. Epub 2002 Sep 26.